Antibiotic susceptibility of acute otitis media pathogens in otitis-prone Belgian children

• Published in: European journal of pediatrics 2004-09, Vol.163 (9), p.524-529
• Main Authors: VAN KEMPEN, Muriel J. P, VANEECHOUTTE, Mario, CLAEYS, Geert, VERSCHRAEGEN, Gerda L. C, VERMEIREN, Judith, DHOOGE, Ingeborg J
• Format: Article
• Language: English
• Subjects: Bacterial diseases; Belgium - epidemiology; Biological and medical sciences; Child; Child, Preschool; Drug Resistance, Bacterial; Ent and stomatologic bacterial diseases; General aspects; Haemophilus influenzae - drug effects; Human bacterial diseases; Humans; In Vitro Techniques; Infant; Infectious diseases; Medical sciences; Microbial Sensitivity Tests; Moraxella (Branhamella) catarrhalis - drug effects; Otitis Media - epidemiology; Otitis Media - microbiology; Prospective Studies; Recurrence; Serotyping; Statistics, Nonparametric; Streptococcus pneumoniae - drug effects
• ISSN: 0340-6199; 1432-1076
• DOI: 10.1007/s00431-004-1475-0

A regional surveillance study was carried out in children with recurrent acute otitis media (AOM) to determine the antimicrobial susceptibility of three common AOM pathogens. Susceptibility to relevant antimicrobial agents was determined on 149 Streptococcus pneumoniae, 246 Haemophilus influenzae and 119 Moraxella catarrhalis strains isolated between January 1999 and January 2002, either from the nasopharynx or middle ear of 74 children with recurrent AOM, the majority (77%) being otitis-prone. Overall pneumococcal resistance to penicillin was 9.4% (6.7% penicillin-intermediate resistant, 2.7% penicillin-resistant), whereas cotrimoxazole and erythromycin resistance accounted for 25.5% and 38.9% respectively. The prevalence of antimicrobial-non-susceptible S. pneumoniae was the highest in middle ear isolates (P