A sugar that benefits failing hearts

Abstract Ischemia is a major etiological factor in the development and progression of congestive heart failure. Current pharmaceutical treatments do not address the underlying metabolic problem within the heart. Adenosine triphosphate levels, critical for the preservation of cellular integrity, intr...

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Bibliographic Details
Published in:International journal of cardiology 2009-01, Vol.131 (3), p.398-398
Main Authors: St.Cyr, J.A, Schneider, Joseph R
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - deficiency
Administration, Oral
Biological and medical sciences
Cardiology. Vascular system
Cardiovascular
Congestive heart failure
Energy Metabolism
Heart
Heart Failure - drug therapy
Heart Failure - metabolism
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Humans
Ischemia
Medical sciences
Ribose
Ribose - administration & dosage
Citations: Items that this one cites
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Description
Summary:Abstract Ischemia is a major etiological factor in the development and progression of congestive heart failure. Current pharmaceutical treatments do not address the underlying metabolic problem within the heart. Adenosine triphosphate levels, critical for the preservation of cellular integrity, intracellular enzymatic reactions, and function, are depleted with myocardial ischemia, and in heart failure as well. Future therapies should look to enhance myocardial energy metabolism in the failing heart.
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2007.08.012