Evaluation of Tumor Angiogenesis Using Dynamic Enhanced Magnetic Resonance Imaging: Comparison of Plasma Vascular Endothelial Growth Factor, Hemodynamic, and Pharmacokinetic Parameters

Purpose: To assess whether tumor angiogenesis of breast cancers can be predicted on the basis of dynamic magnetic resonance imaging (MRI). Material and Methods: Seventy-one patients with 71 breast cancers underwent Gd-DTPA enhanced dynamic MRI. Two regions of interest measurements were obtained in t...

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Bibliographic Details
Published in:Acta radiologica (1987) 2004-07, Vol.45 (4), p.446-452
Main Authors: Ikeda, O., Nishimura, R., Miyayama, H., Yasunaga, T., Ozaki, Y., Tuji, A., Yamashita, Y.
Format: Article
Language:English
Subjects:
Adenocarcinoma - blood
Adenocarcinoma - blood supply
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Breast Neoplasms - blood
Breast Neoplasms - blood supply
Contrast Media - pharmacokinetics
Female
Gadolinium DTPA - pharmacokinetics
Gynecology. Andrology. Obstetrics
Humans
Image Enhancement - methods
Image Processing, Computer-Assisted
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Imaging - methods
Mammary gland diseases
Medical sciences
Middle Aged
Models, Biological
Neovascularization, Pathologic - diagnosis
Permeability
Regional Blood Flow - physiology
Time Factors
Tumors
Vascular Endothelial Growth Factor A - blood
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Summary:Purpose: To assess whether tumor angiogenesis of breast cancers can be predicted on the basis of dynamic magnetic resonance imaging (MRI). Material and Methods: Seventy-one patients with 71 breast cancers underwent Gd-DTPA enhanced dynamic MRI. Two regions of interest measurements were obtained in the periphery and in the center of the breast cancers. Hemodynamic parameters obtained by dynamic MRI included peak time, contrast enhancement ratio (CE ratio), and washout ratio. The triexponential concentration curve of Gd-DTPA was fitted to a theoretical model based on compartmental analysis. The transfer constant (or permeability surface product per unit volume of compartment "k") was obtained using this method. Tumor angiogenesis was assessed by plasma vascular endothelial growth factor (P-VEGF). Results: The P-VEGF was positive in 28 of 71 tumors (39%). The CE ratio, washout ratio, and k in the periphery in P-VEGF positive breast cancers (mean 178%, 18%, and 1.5×10−2 (s−1)) were significantly greater (P
ISSN:0284-1851
1600-0455
DOI:10.1080/02841850410005372