Association between duration of tirofiban therapy before percutaneous intervention and tissue level perfusion (a TACTICS-TIMI 18 substudy)

In the setting of acute coronary syndromes, thrombotic embolization and activation of platelets with release of vasoconstrictors into the downstream microvasculature may occur before cardiac catheterization. In the Treat Angina with tirofiban and determine Cost of Therapy with an Invasive or Conserv...

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Bibliographic Details
Published in:The American journal of cardiology 2004-08, Vol.94 (4), p.492-494
Main Authors: Gibson, C.Michael, Singh, Kanwar P., Murphy, Sabina A., DiBattiste, Peter M., Demopoulos, Laura A., Cannon, Christopher P., Braunwald, Eugene
Format: Article
Language:English
Subjects:
Aged
Angina, Unstable - diagnostic imaging
Angina, Unstable - drug therapy
Angina, Unstable - economics
Angioplasty, Balloon, Coronary - economics
Biological and medical sciences
Cardiac Catheterization - economics
Cardiology. Vascular system
Cardiovascular disease
Catheters
Coronary Angiography - economics
Coronary vessels
Cost-Benefit Analysis
Dose-Response Relationship, Drug
Drug Administration Schedule
Drug therapy
Female
Heart
Humans
Male
Medical sciences
Medical treatment
Microcirculation - drug effects
Middle Aged
Myocardial Infarction - diagnostic imaging
Myocardial Infarction - drug therapy
Myocardial Infarction - economics
Myocardial Reperfusion Injury - diagnostic imaging
Myocardial Reperfusion Injury - economics
Myocardial Reperfusion Injury - prevention & control
Platelet Aggregation Inhibitors - administration & dosage
Platelet Aggregation Inhibitors - adverse effects
Platelet Aggregation Inhibitors - economics
Premedication - economics
Thrombolytic Therapy - economics
Treatment Outcome
Tyrosine - administration & dosage
Tyrosine - adverse effects
Tyrosine - analogs & derivatives
Tyrosine - economics
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Summary:In the setting of acute coronary syndromes, thrombotic embolization and activation of platelets with release of vasoconstrictors into the downstream microvasculature may occur before cardiac catheterization. In the Treat Angina with tirofiban and determine Cost of Therapy with an Invasive or Conservative Strategy-Thrombolysis In Myocardial Infarction 18 (TACTICS-TIMI 18) trial angiographic substudy, a shorter duration of tirofiban infusion before percutaneous coronary intervention was associated with impaired myocardial perfusion before and after intervention.
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2004.04.066