Persistent diastolic dysfunction despite complete systolic functional recovery after reperfused acute myocardial infarction demonstrated by tagged magnetic resonance imaging

Aims This study was designed to characterise both the systolic and diastolic mechanical properties of regions with different degrees of myocardial ischaemic injury after reperfused acute myocardial infarction (AMI). Methods and Results Fourteen dogs underwent 90-min coronary artery occlusion followe...

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Bibliographic Details
Published in:European heart journal 2004-08, Vol.25 (16), p.1419-1427
Main Authors: Azevedo, Clerio F., Amado, Luciano C., Kraitchman, Dara L., Gerber, Bernhard L., Osman, Nael F., Rochitte, Carlos E., Edvardsen, Thor, Lima, Joao A.C.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cardiology. Vascular system
Coronary Circulation - physiology
Coronary heart disease
Diastole - physiology
Dogs
Heart
Heart Rate - physiology
Ligation
Magnetic Resonance Angiography
Medical sciences
Microcirculation
Myocardial Infarction - physiopathology
Myocardial Ischemia - physiopathology
Myocardial Reperfusion
Myocarditis. Cardiomyopathies
Recovery of Function
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Summary:Aims This study was designed to characterise both the systolic and diastolic mechanical properties of regions with different degrees of myocardial ischaemic injury after reperfused acute myocardial infarction (AMI). Methods and Results Fourteen dogs underwent 90-min coronary artery occlusion followed by reperfusion. Image acquisition was performed 24 h after reperfusion using three techniques: tagged, first-pass perfusion and delayed-enhancement magnetic resonance imaging (MRI). Systolic circumferential strain and both systolic and diastolic strain rates were calculated in 30 segments/animal. Transmural AMI segments displayed reduced systolic contractility when compared to subendocardial AMI segments (systolic strain=–2.5±0.5% versus –6.0±0.9%, P
ISSN:0195-668X
1522-9645
DOI:10.1016/j.ehj.2004.06.024