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Persistent diastolic dysfunction despite complete systolic functional recovery after reperfused acute myocardial infarction demonstrated by tagged magnetic resonance imaging

Aims This study was designed to characterise both the systolic and diastolic mechanical properties of regions with different degrees of myocardial ischaemic injury after reperfused acute myocardial infarction (AMI). Methods and Results Fourteen dogs underwent 90-min coronary artery occlusion followe...

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Published in:	European heart journal 2004-08, Vol.25 (16), p.1419-1427
Main Authors:	Azevedo, Clerio F., Amado, Luciano C., Kraitchman, Dara L., Gerber, Bernhard L., Osman, Nael F., Rochitte, Carlos E., Edvardsen, Thor, Lima, Joao A.C.
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Language:	English
Subjects:	Animals Biological and medical sciences Cardiology. Vascular system Coronary Circulation - physiology Coronary heart disease Diastole - physiology Dogs Heart Heart Rate - physiology Ligation Magnetic Resonance Angiography Medical sciences Microcirculation Myocardial Infarction - physiopathology Myocardial Ischemia - physiopathology Myocardial Reperfusion Myocarditis. Cardiomyopathies Recovery of Function
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container_title	European heart journal
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creator	Azevedo, Clerio F. Amado, Luciano C. Kraitchman, Dara L. Gerber, Bernhard L. Osman, Nael F. Rochitte, Carlos E. Edvardsen, Thor Lima, Joao A.C.
description	Aims This study was designed to characterise both the systolic and diastolic mechanical properties of regions with different degrees of myocardial ischaemic injury after reperfused acute myocardial infarction (AMI). Methods and Results Fourteen dogs underwent 90-min coronary artery occlusion followed by reperfusion. Image acquisition was performed 24 h after reperfusion using three techniques: tagged, first-pass perfusion and delayed-enhancement magnetic resonance imaging (MRI). Systolic circumferential strain and both systolic and diastolic strain rates were calculated in 30 segments/animal. Transmural AMI segments displayed reduced systolic contractility when compared to subendocardial AMI segments (systolic strain=–2.5±0.5% versus –6.0±0.9%, P
doi_str_mv	10.1016/j.ehj.2004.06.024
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Methods and Results Fourteen dogs underwent 90-min coronary artery occlusion followed by reperfusion. Image acquisition was performed 24 h after reperfusion using three techniques: tagged, first-pass perfusion and delayed-enhancement magnetic resonance imaging (MRI). Systolic circumferential strain and both systolic and diastolic strain rates were calculated in 30 segments/animal. Transmural AMI segments displayed reduced systolic contractility when compared to subendocardial AMI segments (systolic strain=–2.5±0.5% versus –6.0±0.9%, P<0.01 and systolic strain rate=–0.11±0.12 versus –0.82±0.16 s–1, P<0.01), and both exhibited significant systolic and diastolic dysfunction compared to remote. Moreover, AMI segments presenting with microvascular obstruction ("no-reflow") displayed further compromise of systolic and diastolic regional function (P<0.05 for both). Importantly, risk region segments only exhibited diastolic impairment (diastolic strain rate=1.62±0.14 versus 2.99±0.13 s–1, P<0.001), but not systolic dysfunction compared to remote 24 h after reperfusion. Conclusion Reversibly injured regions can demonstrate persistent diastolic dysfunction despite complete systolic functional recovery after reperfused AMI. Moreover, the presence of no-reflow entails profound systolic and diastolic dysfunction. Finally, tagged magnetic resonance imaging (MRI) strain rate analysis provides detailed mechanical characterisation of regions with different degrees of myocardial ischaemic injury.</description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1016/j.ehj.2004.06.024</identifier><identifier>PMID: 15321700</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Animals ; Biological and medical sciences ; Cardiology. Vascular system ; Coronary Circulation - physiology ; Coronary heart disease ; Diastole - physiology ; Dogs ; Heart ; Heart Rate - physiology ; Ligation ; Magnetic Resonance Angiography ; Medical sciences ; Microcirculation ; Myocardial Infarction - physiopathology ; Myocardial Ischemia - physiopathology ; Myocardial Reperfusion ; Myocarditis. Cardiomyopathies ; Recovery of Function</subject><ispartof>European heart journal, 2004-08, Vol.25 (16), p.1419-1427</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-d0ffaf8a848c6fd9651dcb5b90c0cb8230b598d2798e3fd7d9eca53f3ef54a463</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16024107$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15321700$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Azevedo, Clerio F.</creatorcontrib><creatorcontrib>Amado, Luciano C.</creatorcontrib><creatorcontrib>Kraitchman, Dara L.</creatorcontrib><creatorcontrib>Gerber, Bernhard L.</creatorcontrib><creatorcontrib>Osman, Nael F.</creatorcontrib><creatorcontrib>Rochitte, Carlos E.</creatorcontrib><creatorcontrib>Edvardsen, Thor</creatorcontrib><creatorcontrib>Lima, Joao A.C.</creatorcontrib><title>Persistent diastolic dysfunction despite complete systolic functional recovery after reperfused acute myocardial infarction demonstrated by tagged magnetic resonance imaging</title><title>European heart journal</title><addtitle>Eur Heart J</addtitle><description>Aims This study was designed to characterise both the systolic and diastolic mechanical properties of regions with different degrees of myocardial ischaemic injury after reperfused acute myocardial infarction (AMI). Methods and Results Fourteen dogs underwent 90-min coronary artery occlusion followed by reperfusion. Image acquisition was performed 24 h after reperfusion using three techniques: tagged, first-pass perfusion and delayed-enhancement magnetic resonance imaging (MRI). Systolic circumferential strain and both systolic and diastolic strain rates were calculated in 30 segments/animal. Transmural AMI segments displayed reduced systolic contractility when compared to subendocardial AMI segments (systolic strain=–2.5±0.5% versus –6.0±0.9%, P<0.01 and systolic strain rate=–0.11±0.12 versus –0.82±0.16 s–1, P<0.01), and both exhibited significant systolic and diastolic dysfunction compared to remote. Moreover, AMI segments presenting with microvascular obstruction ("no-reflow") displayed further compromise of systolic and diastolic regional function (P<0.05 for both). Importantly, risk region segments only exhibited diastolic impairment (diastolic strain rate=1.62±0.14 versus 2.99±0.13 s–1, P<0.001), but not systolic dysfunction compared to remote 24 h after reperfusion. Conclusion Reversibly injured regions can demonstrate persistent diastolic dysfunction despite complete systolic functional recovery after reperfused AMI. Moreover, the presence of no-reflow entails profound systolic and diastolic dysfunction. Finally, tagged magnetic resonance imaging (MRI) strain rate analysis provides detailed mechanical characterisation of regions with different degrees of myocardial ischaemic injury.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Coronary Circulation - physiology</subject><subject>Coronary heart disease</subject><subject>Diastole - physiology</subject><subject>Dogs</subject><subject>Heart</subject><subject>Heart Rate - physiology</subject><subject>Ligation</subject><subject>Magnetic Resonance Angiography</subject><subject>Medical sciences</subject><subject>Microcirculation</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Myocardial Ischemia - physiopathology</subject><subject>Myocardial Reperfusion</subject><subject>Myocarditis. Cardiomyopathies</subject><subject>Recovery of Function</subject><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNpFkcuO1DAQRS0EYpqBD2CDvIFdgp2HkyzRCGhES6DhoRYby7HLjZu8xnZGk4_iH6lWZ5iVy-VT91p1CXnJWcoZF2-PKfw-phljRcpEyrLiEdnwMsuSRhTlY7JhvCkTIer9BXkWwpExVgsunpILXuYZrxjbkL9fwQcXIgyRGqdCHDunqVmCnQcd3ThQA2FyEage-6kDLMKyUveI6qgHPd6CX6iyETxeJ_B2DmCo0jPO9MuolUeDjrrBKn8v3Y9DiF5FBNuFRnU4YNWrwwARDTwEVB80UIc9NxyekydWdQFerOcl-fHh_ferbbL78vHT1btdoouqiIlh1ipbq7qotbCmESU3ui3bhmmm2zrLWVs2tcmqpobcmso0oFWZ2xxsWahC5JfkzVl38uPNDCHK3gUNXacGGOcgcaecs4ojyM-g9mMIHqycPP7VL5IzecpIHiVmJE8ZSSYkZoQzr1bxue3BPEysoSDwegVU0KqzHlfgwgMnUAXdkUvO3Cm_u__vyv-RosqrUm73v-T28_W3n7v9tSzyf-RJsbY</recordid><startdate>20040801</startdate><enddate>20040801</enddate><creator>Azevedo, Clerio F.</creator><creator>Amado, Luciano C.</creator><creator>Kraitchman, Dara L.</creator><creator>Gerber, Bernhard L.</creator><creator>Osman, Nael F.</creator><creator>Rochitte, Carlos E.</creator><creator>Edvardsen, Thor</creator><creator>Lima, Joao A.C.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040801</creationdate><title>Persistent diastolic dysfunction despite complete systolic functional recovery after reperfused acute myocardial infarction demonstrated by tagged magnetic resonance imaging</title><author>Azevedo, Clerio F. ; Amado, Luciano C. ; Kraitchman, Dara L. ; Gerber, Bernhard L. ; Osman, Nael F. ; Rochitte, Carlos E. ; Edvardsen, Thor ; Lima, Joao A.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-d0ffaf8a848c6fd9651dcb5b90c0cb8230b598d2798e3fd7d9eca53f3ef54a463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Coronary Circulation - physiology</topic><topic>Coronary heart disease</topic><topic>Diastole - physiology</topic><topic>Dogs</topic><topic>Heart</topic><topic>Heart Rate - physiology</topic><topic>Ligation</topic><topic>Magnetic Resonance Angiography</topic><topic>Medical sciences</topic><topic>Microcirculation</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Myocardial Ischemia - physiopathology</topic><topic>Myocardial Reperfusion</topic><topic>Myocarditis. Cardiomyopathies</topic><topic>Recovery of Function</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Azevedo, Clerio F.</creatorcontrib><creatorcontrib>Amado, Luciano C.</creatorcontrib><creatorcontrib>Kraitchman, Dara L.</creatorcontrib><creatorcontrib>Gerber, Bernhard L.</creatorcontrib><creatorcontrib>Osman, Nael F.</creatorcontrib><creatorcontrib>Rochitte, Carlos E.</creatorcontrib><creatorcontrib>Edvardsen, Thor</creatorcontrib><creatorcontrib>Lima, Joao A.C.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Azevedo, Clerio F.</au><au>Amado, Luciano C.</au><au>Kraitchman, Dara L.</au><au>Gerber, Bernhard L.</au><au>Osman, Nael F.</au><au>Rochitte, Carlos E.</au><au>Edvardsen, Thor</au><au>Lima, Joao A.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Persistent diastolic dysfunction despite complete systolic functional recovery after reperfused acute myocardial infarction demonstrated by tagged magnetic resonance imaging</atitle><jtitle>European heart journal</jtitle><addtitle>Eur Heart J</addtitle><date>2004-08-01</date><risdate>2004</risdate><volume>25</volume><issue>16</issue><spage>1419</spage><epage>1427</epage><pages>1419-1427</pages><issn>0195-668X</issn><eissn>1522-9645</eissn><abstract>Aims This study was designed to characterise both the systolic and diastolic mechanical properties of regions with different degrees of myocardial ischaemic injury after reperfused acute myocardial infarction (AMI). Methods and Results Fourteen dogs underwent 90-min coronary artery occlusion followed by reperfusion. Image acquisition was performed 24 h after reperfusion using three techniques: tagged, first-pass perfusion and delayed-enhancement magnetic resonance imaging (MRI). Systolic circumferential strain and both systolic and diastolic strain rates were calculated in 30 segments/animal. Transmural AMI segments displayed reduced systolic contractility when compared to subendocardial AMI segments (systolic strain=–2.5±0.5% versus –6.0±0.9%, P<0.01 and systolic strain rate=–0.11±0.12 versus –0.82±0.16 s–1, P<0.01), and both exhibited significant systolic and diastolic dysfunction compared to remote. Moreover, AMI segments presenting with microvascular obstruction ("no-reflow") displayed further compromise of systolic and diastolic regional function (P<0.05 for both). Importantly, risk region segments only exhibited diastolic impairment (diastolic strain rate=1.62±0.14 versus 2.99±0.13 s–1, P<0.001), but not systolic dysfunction compared to remote 24 h after reperfusion. Conclusion Reversibly injured regions can demonstrate persistent diastolic dysfunction despite complete systolic functional recovery after reperfused AMI. Moreover, the presence of no-reflow entails profound systolic and diastolic dysfunction. Finally, tagged magnetic resonance imaging (MRI) strain rate analysis provides detailed mechanical characterisation of regions with different degrees of myocardial ischaemic injury.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>15321700</pmid><doi>10.1016/j.ehj.2004.06.024</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record>
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subjects	Animals Biological and medical sciences Cardiology. Vascular system Coronary Circulation - physiology Coronary heart disease Diastole - physiology Dogs Heart Heart Rate - physiology Ligation Magnetic Resonance Angiography Medical sciences Microcirculation Myocardial Infarction - physiopathology Myocardial Ischemia - physiopathology Myocardial Reperfusion Myocarditis. Cardiomyopathies Recovery of Function
title	Persistent diastolic dysfunction despite complete systolic functional recovery after reperfused acute myocardial infarction demonstrated by tagged magnetic resonance imaging
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