Sensitization and allergy to turnip rape: a comparison between the Finnish and French children with atopic dermatitis

• Published in: Acta Paediatrica 2009-02, Vol.98 (2), p.310-315
• Main Authors: Poikonen, S, Rancé, F, Puumalainen, TJ, Le Manach, G, Reunala, T, Turjanmaa, K
• Format: Article
• Language: English
• Subjects: Allergic diseases; Atopic dermatitis; Biological and medical sciences; Brassica napus - adverse effects; Brassica napus - immunology; Child; Child, Preschool; Cross Reactions; Dermatitis, Atopic - etiology; Dermatitis, Atopic - immunology; Digestive allergic diseases; Female; Finland; Food allergy; Food Hypersensitivity - complications; Food Hypersensitivity - immunology; France; General aspects; Humans; Immunoglobulin E - immunology; Immunopathology; Infant; Male; Medical sciences; Mustard; Mustard Plant - immunology; Oilseed rape; Skin allergic diseases. Stinging insect allergies; Turnip rape
• ISSN: 0803-5253; 1651-2227
• DOI: 10.1111/j.1651-2227.2008.01020.x

Aim: Finnish children with atopic dermatitis (AD) are frequently sensitized and show positive food challenge to turnip rape. We examined whether French children are also allergic to this oilseed plant and whether mustard could be the cross‐reacting allergen. Methods: Turnip rape and mustard challenge was performed to 14 Finnish and 14 French children with atopic dermatitis and positive skin prick test to turnip rape. Specific IgE antibodies were measured by ImmunoCAP and enzyme‐linked immunosorbent assay (ELISA). Results: Open labial or oral challenge to turnip rape was positive in 14 (100%) Finnish and five (36%) French children and mustard challenge in five Finnish and five French children. IgE antibodies to oilseed rape and mustard were slightly more frequent in the Finnish (100% and 93%) than in the French (93% and 71%) children but rare (4%) in the 28 matched controls. The same findings were true for IgE antibodies to purified 2S albumin allergens, which showed similar cross‐wise IgE inhibition patterns. Conclusion: French children with atopic dermatitis show IgE antibodies to turnip rape, oilseed rape and mustard similarly to the Finnish children. 2S albumin allergens in the seeds of these plants are highly cross‐reactive and therefore, they all could be important sensitizers in children with atopic dermatitis.