Two novel MICA alleles, MICA054 and MICA056

We report the identification of two novel major histocompatibility complex (MHC) class I‐related chain A (MICA) alleles. MICA*054 has a nucleotide substitution of A to G at position 871 (codon 268), encoding an amino acid change of serine to glycine in the α‐3 domain. MICA*056 has a nucleotide subst...

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Bibliographic Details
Published in:Tissue antigens 2009-01, Vol.73 (1), p.85-87
Main Authors: Cox, S. T., Stephens, H. A. F, Fernando, R., Grant, J., Madrigal, J. A., Little, A.-M.
Format: Article
Language:English
Subjects:
Alleles
Amino Acid Substitution - genetics
Base Sequence
Exons - genetics
Histocompatibility Antigens Class I - genetics
Humans
MHC polymorphism
MICA054
MICA056
Molecular Sequence Data
renal
SBT
Sequence Alignment
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Summary:We report the identification of two novel major histocompatibility complex (MHC) class I‐related chain A (MICA) alleles. MICA*054 has a nucleotide substitution of A to G at position 871 (codon 268), encoding an amino acid change of serine to glycine in the α‐3 domain. MICA*056 has a nucleotide substitution at position 758 of G to C resulting in the substitution of tryptophan for serine at codon 230, also in the α‐3 domain.
ISSN:0001-2815
1399-0039
DOI:10.1111/j.1399-0039.2008.01173.x