Histone H1 and its isoforms: Contribution to chromatin structure and function

The lysine-rich H1 histone family in mammals includes eleven different subtypes, and thus it is the most divergent class of histone proteins. The central globular H1 domain asymmetrically interacts with DNA at the exit or entry end of the nucleosomal core DNA, and the C-terminal domain has a major i...

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Bibliographic Details
Published in:Gene 2009-02, Vol.431 (1), p.1-12
Main Authors: Happel, Nicole, Doenecke, Detlef
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Chromatin - chemistry
Chromatin - metabolism
Chromatin dynamics
Conserved Sequence
Histone phosphorylation
Histones - chemistry
Histones - genetics
Histones - metabolism
Humans
Linker histone
Mammals - metabolism
Molecular Sequence Data
Nucleosome
Protein Binding
Protein Isoforms - chemistry
Protein Isoforms - genetics
Protein Isoforms - metabolism
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Summary:The lysine-rich H1 histone family in mammals includes eleven different subtypes, and thus it is the most divergent class of histone proteins. The central globular H1 domain asymmetrically interacts with DNA at the exit or entry end of the nucleosomal core DNA, and the C-terminal domain has a major impact on the linker DNA conformation and chromatin condensation. H1 histones are thus involved in the formation of higher order chromatin structures, and they modulate the accessibility of regulatory proteins, chromatin remodeling factors and histone modification enzymes to their target sites. The major posttranslational modification of H1 histones is phosphorylation, which reaches a peak during G2 and mitosis. Phosphorylation is, however, also involved in the control of DNA replication and it contributes to the regulation of gene expression. Disruption of linker histone genes, initially performed in order to delineate subtype-specific functions, revealed that disruption of one or two H1 subtype genes is quantitatively compensated by an increased expression of other subtypes. This suggests a functional redundancy among H1 subtypes. However, the inactivation of three subtypes and the reduction of the H1 moiety in half finally resulted in a phenotypic effect. On the other hand, studies on the role of particular subtypes at specific developmental stages in lower eukaryotes, but also in vertebrates suggest that specific subtypes of H1 participate in particular systems of gene regulation.
ISSN:0378-1119
1879-0038
DOI:10.1016/j.gene.2008.11.003