Coxsackie B viruses use multiple receptors to infect human cardiac cells

Viral myocarditis is an inflammatory disease of the heart muscle that can be fatal. The primary viruses that have been linked to myocarditis and dilated cardiomyopathy are the human enteroviruses. The most common viruses associated with this disease are the Coxsackie B viruses and in particular Coxs...

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Bibliographic Details
Published in:Journal of medical virology 2004-10, Vol.74 (2), p.291-299
Main Authors: Orthopoulos, George, Triantafilou, Kathy, Triantafilou, Martha
Format: Article
Language:English
Subjects:
Adenovirus
Adult
Biological and medical sciences
CAR
CD55
CD55 Antigens - metabolism
Cell Line
Cells, Cultured
Coxsackie and Adenovirus Receptor-Like Membrane Protein
Coxsackievirus B3
Coxsackievirus B5
Enterovirus B, Human - pathogenicity
Female
Fundamental and applied biological sciences. Psychology
Human viral diseases
Humans
Infectious diseases
Medical sciences
Microbiology
Miscellaneous
Muscle Cells - virology
Myocardium - cytology
Receptors, Virus - antagonists & inhibitors
Receptors, Virus - metabolism
Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
Viral diseases
Virology
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Summary:Viral myocarditis is an inflammatory disease of the heart muscle that can be fatal. The primary viruses that have been linked to myocarditis and dilated cardiomyopathy are the human enteroviruses. The most common viruses associated with this disease are the Coxsackie B viruses and in particular Coxsackievirus B3 and Coxsackievirus B5. Early events in viral infection include attachment of the virus onto cell surface receptors. Even though, CD55 and Coxsackievirus adenovirus receptor protein (CAR) have been identified as receptors for Coxsackievirus B3, the exact mechanisms that Coxsackievirus B3 and B5 use to infect the cardiac muscle are not yet known. In this study, attempts were made to inhibit Coxsackievirus B3 and Coxsackievirus B5 infectivity of cardiac cells by using CAR and CD55 specific antibodies. The results show that these antibodies could not completely inhibit Coxsackievirus B3 and Coxsackievirus B5 binding or infectivity. Furthermore five new proteins have been identified that are used by Coxsackieviruses for binding to cardiac tissue and are distinct from CAR or CD55, leading us to believe that these viruses may use a different set of receptors for infection of cardiac muscle. J. Med. Virol. 74:291–299, 2004. © 2004 Wiley‐Liss, Inc.
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.20184