Magnetoresistive-based biosensors and biochips

Over the past five years, magnetoelectronics has emerged as a promising new platform technology for biosensor and biochip development. The techniques are based on the detection of the magnetic fringe field of a magnetically labeled biomolecule interacting with a complementary biomolecule bound to a...

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Bibliographic Details
Published in:Trends in biotechnology (Regular ed.) 2004-09, Vol.22 (9), p.455-462
Main Authors: Graham, Daniel L., Ferreira, Hugo A., Freitas, Paulo P.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biosensing Techniques - instrumentation
Biosensing Techniques - methods
Biosensing Techniques - trends
Biosensors
Biotechnology
Biotin - chemistry
DNA Probes - chemistry
DNA Probes - genetics
Electric Impedance
Ferric Compounds - chemistry
Fundamental and applied biological sciences. Psychology
Lab-On-A-Chip Devices
Magnetics
Methods. Procedures. Technologies
Microchip Analytical Procedures - methods
Microspheres
Nanostructures - chemistry
Nanotechnology
Nucleic Acid Hybridization - methods
Streptavidin - chemistry
Various methods and equipments
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Summary:Over the past five years, magnetoelectronics has emerged as a promising new platform technology for biosensor and biochip development. The techniques are based on the detection of the magnetic fringe field of a magnetically labeled biomolecule interacting with a complementary biomolecule bound to a magnetic-field sensor. Magnetoresistive-based sensors, conventionally used as read heads in hard disk drives, have been used in combination with biologically functionalized magnetic labels to demonstrate the detection of molecular recognition. Real-world bio-applications are now being investigated, enabling tailored device design, based on sensor and label characteristics. This detection platform provides a robust, inexpensive sensing technique with high sensitivity and considerable scope for quantitative signal data, enabling magnetoresistive biochips to meet specific diagnostic needs that are not met by existing technologies.
ISSN:0167-7799
1879-3096
DOI:10.1016/j.tibtech.2004.06.006