Changes of body composition in bulimia nervosa: increased visceral fat and adrenal gland size

• Published in: Psychosomatic medicine 2009-01, Vol.71 (1), p.93-97
• Main Authors: Ludescher, Burkhard, Leitlein, Gabriele, Schaefer, Jacques-Emmanuel, Vanhoeffen, Stefanie, Baar, Sophia, Machann, Juergen, Claussen, Claus D, Schick, Fritz, Eschweiler, Gerhard W
• Format: Article
• Language: English
• Subjects: Adrenal glands; Adrenal Glands - pathology; Adult; Amenorrhea - epidemiology; Body Composition; Body fat; Body Mass Index; Bulimia; Bulimia - pathology; Bulimia nervosa; Contraceptives, Oral; Cushing Syndrome - pathology; Depression - epidemiology; Female; Hormones; Human body; Humans; Hydrocortisone - analysis; Hypertrophy; Intra-Abdominal Fat - pathology; Magnetic Resonance Imaging; Muscle, Skeletal - pathology; Pilot Projects; Psychosomatic medicine; Saliva - chemistry; Smoking - epidemiology; Stress; Women; Young Adult
• ISSN: 0033-3174; 1534-7796
• DOI: 10.1097/PSY.0b013e3181904f59

To study the hypothesis that young women suffering from active bulimia nervosa (BN) have more visceral fat and increased adrenal gland volumes (AGV) than healthy controls (HC). Thirteen patients with BN of purging type and 11 healthy age and weight matched women (HC), aged between 19 and 36 years (mean 24 +/- 3 years), with a BMI of 19 to 29 (mean 24 +/- SD 3) were examined. BN was diagnosed by DSM-IV criteria and the severity of illness by the Eating Disorder Inventory (EDI-2). Whole body fat distribution and AGV were determined using a whole body magnetic resonance (MR) scan (T1w) and a 3D-sequence (T1w) at 1.5 Tesla. Salivary cortisol was determined at 9 AM and 4 PM. BN patients had significantly more visceral adipose tissue (VAT) (HC, 1589.3 +/- 967.6 ml versus 927.2 +/- 428.4 ml, p < .05) and an increased relative AGV (0.068% of body volume versus 0.048% of body volume, p < .05) compared with HC, although waist circumference and BMI did not differ. Although the VAT part in the upper abdomen was increased, especially the VAT of lower abdomen along with the pelvis or any subcutaneous fat compartment was not increased. The increase of the VAT volume and the increased AGV in BN women with purging point to chronic high stress levels associated with a hyperactivity of the hypothalamic-pituitary-adrenal axis in these patients. This is the first MR study showing morphological changes in stress associated endocrine organs of young BN patients.