Reversible posterior leuko-encephalopathy in children with sickle cell disease

Children with sickle cell disease (SCD) have high risk of neurologic morbidity and mortality, such as strokes, silent infarcts and TIA's. A retrospective review of magnetic resonance imaging and magnetic resonance angiography identified eight children with radiological and clinical characterist...

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Bibliographic Details
Published in:Pediatric Blood & Cancer 2009-03, Vol.52 (3), p.373-375
Main Authors: Khademian, Zarir, Speller-Brown, Barbara, Nouraie, Seyed-Medhi, Minniti, Caterina P.
Format: Article
Language:English
Subjects:
Adolescent
Anemia, Sickle Cell - complications
Anemia, Sickle Cell - diagnostic imaging
Child
Female
Follow-Up Studies
hemoglobinopathies
Humans
Male
neurology and sickle cell
Posterior Leukoencephalopathy Syndrome - complications
Posterior Leukoencephalopathy Syndrome - diagnostic imaging
Radiography
sickle cell disease
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Summary:Children with sickle cell disease (SCD) have high risk of neurologic morbidity and mortality, such as strokes, silent infarcts and TIA's. A retrospective review of magnetic resonance imaging and magnetic resonance angiography identified eight children with radiological and clinical characteristics of reversible posterior encephalopathy (RPLS). These patients had no evidence of previous cerebral infarcts or vasculopathy. Three have died during the 5‐year follow up; one developed a stroke and one a conditional TCD. RPLS needs to be considered in the differential diagnosis of children with SCD that present with acute neurological changes, especially if they are already been hospitalized. Pediatr Blood Cancer 2009;52:373–375. © 2008 Wiley‐Liss, Inc.
ISSN:1545-5009
1545-5017
1096-911X
DOI:10.1002/pbc.21812