Association of K-ras Mutations with Liver Metastases from Colorectal Carcinoma

Background: Colorectal carcinomas were studied regarding early proof of liver metastases through determination of K-ras mutations. Patients and Methods: Seventy-seven colorectal carcinomas were investigated for the presence of point mutations in codon 12 and 13 of the K-ras gene, using single-strand...

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Bibliographic Details
Published in:Anticancer research 2004-07, Vol.24 (4), p.2471-2476
Main Authors: TSUNODA, Akira, IIJIMA, Takeru, TSUNODA, Yuko, NAKAO, Kentaroh, MIYAKI, Michiko, KUSANO, Mitsuo
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Colorectal Neoplasms - genetics
Colorectal Neoplasms - pathology
Female
Gastroenterology. Liver. Pancreas. Abdomen
Genes, ras - genetics
Genetic Predisposition to Disease
Humans
Liver Neoplasms - genetics
Liver Neoplasms - secondary
Male
Medical sciences
Middle Aged
Point Mutation
Predictive Value of Tests
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
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Summary:Background: Colorectal carcinomas were studied regarding early proof of liver metastases through determination of K-ras mutations. Patients and Methods: Seventy-seven colorectal carcinomas were investigated for the presence of point mutations in codon 12 and 13 of the K-ras gene, using single-strand conformation polymorphism (SSCP) analysis and direct sequencing. Results: Twenty-six carcinomas were positive for K-ras mutations, of which 21 had codon 12 and 5 had codon 13 mutations. Twenty patients with K-ras-positive tumor (20 out of 26: 77%) developed liver metastases, of which 13 had simultaneous metastases and 7 had metachronous metastases. There was a significant association between K-ras mutations and liver metastases (p=0.03). A multivariate logistic regression model demonstrated that the involvement of lymph node (p
ISSN:0250-7005
1791-7530