The effect of indocyanine green pretreatment on the parameters of transscleral diode laser thermotherapy-induced threshold coagulation of the ciliary body

Background and Objective To study the effect of indocyanine green (ICG) pretreatment on threshold parameters of transscleral diode laser thermotherapy‐induced threshold coagulation of the ciliary body. The procedure was termed ‘cyclothermotherapy’ based on the long duration (15–60 seconds) of diode...

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Bibliographic Details
Published in:Lasers in surgery and medicine 2004-08, Vol.35 (2), p.157-162
Main Authors: Kuo, Po-Cheng, Peyman, Gholam A., Men, Gamze, Bezerra, Yanno, Torres, Franco
Format: Article
Language:English
Subjects:
Animals
Ciliary Body - drug effects
Ciliary Body - surgery
dye-enhanced thermotherapy
glaucoma
Indocyanine Green - pharmacology
Laser Coagulation
laser therapy
Preoperative Care
Rabbits
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Summary:Background and Objective To study the effect of indocyanine green (ICG) pretreatment on threshold parameters of transscleral diode laser thermotherapy‐induced threshold coagulation of the ciliary body. The procedure was termed ‘cyclothermotherapy’ based on the long duration (15–60 seconds) of diode laser application. Study Design/Materials and Methods The right eyes of nine young adult New Zealand white rabbits underwent transscleral cyclothermotherapy (TCT, Group 1), TCT following ICG pretreatment (Group 2), and external manipulation of the ciliary body alone (Group 3). Rabbits were sacrificed after 24 hours; specimens were evaluated with gross examination and light microscopy. Results Thresholds were 30 J/cm2 (TCT) and 4.5 J/cm2 (TCT with ICG). Widespread structural damage was seen in the ciliary processes and the ciliary body in Groups 1 and 2. In Group 3, external manipulation of the ciliary body caused hemorrhage and structural damage confined to the ciliary processes. Conclusion ICG pretreatment reduced the energy necessary to cause a threshold lesion with TCT in nonpigmented rabbits. Lasers Surg. Med. 35:157–162, 2004. © 2004 Wiley‐Liss, Inc.
ISSN:0196-8092
1096-9101
DOI:10.1002/lsm.20034