Diazepinomicin, a New Antimicrobial Alkaloid from a Marine Micromonospora sp.

The structure of a new dibenzodiazepine alkaloid, diazepinomicin (1), isolated from the culture of a marine actinomycete of the genus Micromonospora was characterized using spectroscopic methods. Diazepinomicin represents a unique molecular class composed of a dibenzodiazepine core linked to a farne...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2004-08, Vol.67 (8), p.1431-1433
Main Authors: Charan, Romila D, Schlingmann, Gerhard, Janso, Jeffrey, Bernan, Valerie, Feng, Xidong, Carter, Guy T
Format: Article
Language:English
Subjects:
Actinomycetes
Alkaloids - chemistry
Alkaloids - isolation & purification
Alkaloids - pharmacology
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Antibiotics (antibacterial agents, antifungal agents)
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Applied microbiology
Biological and medical sciences
Dibenzazepines - chemistry
Dibenzazepines - isolation & purification
Dibenzazepines - pharmacology
Fundamental and applied biological sciences. Psychology
Gram-Positive Bacteria - drug effects
Japan
Marine
Microbial Sensitivity Tests
Microbiology
Micromonospora
Micromonospora - chemistry
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
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Summary:The structure of a new dibenzodiazepine alkaloid, diazepinomicin (1), isolated from the culture of a marine actinomycete of the genus Micromonospora was characterized using spectroscopic methods. Diazepinomicin represents a unique molecular class composed of a dibenzodiazepine core linked to a farnesyl side chain.
ISSN:0163-3864
1520-6025
DOI:10.1021/np040042r