TRPV6 and prostate cancer: cancer growth beyond the prostate correlates with increased TRPV6 Ca2+ channel expression

Life expectancy for patients suffering from prostate cancer is inversely correlated with the degree of extraprostatic metastasis. In order to find pharmacological tools to treat this aggressive growth it is important to define targets whose expression not only correlates with the malignancy of the c...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2004-10, Vol.322 (4), p.1359-1363
Main Authors: Wissenbach, Ulrich, Niemeyer, Barbara, Himmerkus, Nina, Fixemer, Thomas, Bonkhoff, Helmut, Flockerzi, Veit
Format: Article
Language:English
Subjects:
Calcium Channels - metabolism
Calcium Channels - physiology
Cell Proliferation
Humans
Male
Prostate - metabolism
Prostatic Neoplasms - etiology
Prostatic Neoplasms - metabolism
Prostatic Neoplasms - pathology
TRPV Cation Channels
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Summary:Life expectancy for patients suffering from prostate cancer is inversely correlated with the degree of extraprostatic metastasis. In order to find pharmacological tools to treat this aggressive growth it is important to define targets whose expression not only correlates with the malignancy of the cancerous cells, but that are also amenable to pharmacological intervention. In this review, we would like to focus on the potential role of a distinct class of ion channels that may be involved in this process.
ISSN:0006-291X
DOI:10.1016/j.bbrc.2004.08.042