Lipoprotein biogenesis in Gram-positive bacteria: knowing when to hold ‘em, knowing when to fold ‘em

Gram-positive bacterial lipoproteins are a functionally diverse and important class of peripheral membrane proteins. Recent advances in molecular biology and the availability of whole genome sequence data have overturned many long-held assumptions about the export and processing of these proteins, m...

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Bibliographic Details
Published in:Trends in microbiology (Regular ed.) 2009-01, Vol.17 (1), p.13-21
Main Authors: Hutchings, Matthew I, Palmer, Tracy, Harrington, Dean J, Sutcliffe, Iain C
Format: Article
Language:English
Subjects:
Animals
Bacterial Proteins - biosynthesis
Bacterial Proteins - chemistry
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Gene Expression Regulation, Bacterial
Gram-Positive Bacteria - metabolism
Gram-Positive Bacteria - pathogenicity
Gram-Positive Bacterial Infections - microbiology
Humans
Internal Medicine
Lipoproteins - biosynthesis
Lipoproteins - chemistry
Lipoproteins - genetics
Lipoproteins - metabolism
Mice
Protein Folding
Protein Transport
Virulence
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Summary:Gram-positive bacterial lipoproteins are a functionally diverse and important class of peripheral membrane proteins. Recent advances in molecular biology and the availability of whole genome sequence data have overturned many long-held assumptions about the export and processing of these proteins, most notably the recent discovery that not all lipoproteins are exported as unfolded substrates through the general secretion pathway. Here, we review recent discoveries concerning the export and processing of these proteins, their role in virulence in Gram-positive bacteria and their potential as vaccine candidates or targets for new antimicrobials.
ISSN:0966-842X
1878-4380
DOI:10.1016/j.tim.2008.10.001