Decline of T cell-related immune functions in cancer patients and an attempt to restore them through infusion of activated autologous T cells

We developed a scoring system that can combine several immunological parameters and express the immune status of individuals as a simple numeral. T cell immune score was obtained by using 5T cell-related parameters: number of T cells, ratio of CD4+T cells to CD8+T cells, number of naïve T cells, rat...

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Bibliographic Details
Published in:Mechanisms of ageing and development 2009-01, Vol.130 (1-2), p.86-91
Main Authors: Hirokawa, Katsuiku, Utsuyama, Masanori, Ishikawa, Toshiaki, Kikuchi, Yuko, Kitagawa, Masanobu, Fujii, Yuzo, Nariuchi, Hideo, Uetake, Hiroyuki, Sugihara, Kenichi
Format: Article
Language:English
Subjects:
Adoptive Transfer - methods
Aged
Ageing
Aging - immunology
Cancer
CD4-CD8 Ratio
Cell Division - immunology
Cells, Cultured
Colorectal Neoplasms - immunology
Colorectal Neoplasms - pathology
Colorectal Neoplasms - therapy
Disease Progression
Female
Flow Cytometry - methods
Humans
Immunologic Memory - immunology
Immunological intervention
Lymphocyte Activation - immunology
Male
Middle Aged
Scoring system
T cell immunity
T-Lymphocytes - cytology
T-Lymphocytes - immunology
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Summary:We developed a scoring system that can combine several immunological parameters and express the immune status of individuals as a simple numeral. T cell immune score was obtained by using 5T cell-related parameters: number of T cells, ratio of CD4+T cells to CD8+T cells, number of naïve T cells, ratio of naïve T cells to memory T cells, and T cell proliferative index (TCPI). TCPI was calculated by using number of T cells and their proliferative activity. We assessed T cell immune score in 103 patients with colorectal cancer and 51 healthy age-matched controls. The results were as follows: (1) T cell-immune score of patients in stages I–IV before surgery was significantly decreased as compared with controls. (2) The number of regulatory T cells in patients in stages I–IV gradually increased with disease progression. (3) T cell immune score was strongly suppressed after surgery, but were recovered to the initial level within a month. (4) Furthermore, restoration of immunological function was attempted in cancer patients by infusion of activated autologous T cells. The effectiveness was confirmed by an increase of TCPI in many cancer patients.
ISSN:0047-6374
1872-6216
DOI:10.1016/j.mad.2008.05.001