Exaggerated responses to stress in the BTBR T+tf/J mouse: An unusual behavioral phenotype

This study shows that the BTBR T+tf/J mouse, a model for autism spectrum disorder (ASD), has increased levels of the stress hormone corticosterone, when compared to C57BL/6J mice. In addition, we have shown that tail suspension of the BTBR produces a heightened anxiety response in the elevated plus...

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Bibliographic Details
Published in:Behavioural brain research 2009-02, Vol.197 (2), p.462-465
Main Authors: Benno, Robert, Smirnova, Yelena, Vera, Susy, Liggett, Amanda, Schanz, Norman
Format: Article
Language:English
Subjects:
Animals
Anxiety
Anxiety - physiopathology
Anxiety - psychology
Autism spectrum disorder
Autistic Disorder - genetics
Autistic Disorder - physiopathology
Autistic Disorder - psychology
Behavior
Behavioral psychophysiology
Biological and medical sciences
Blood corticosterone levels
BTBR mouse
Child clinical studies
Corticosterone - blood
Developmental disorders
Disease Models, Animal
Elevated plus maze
Enzyme-Linked Immunosorbent Assay
Exploratory Behavior - physiology
Fundamental and applied biological sciences. Psychology
Infantile autism
Male
Maze Learning - physiology
Medical sciences
Mice
Mice, Inbred C57BL
Mice, Inbred Strains
Phenotype
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Psychopathology. Psychiatry
Stress, Physiological - physiology
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Summary:This study shows that the BTBR T+tf/J mouse, a model for autism spectrum disorder (ASD), has increased levels of the stress hormone corticosterone, when compared to C57BL/6J mice. In addition, we have shown that tail suspension of the BTBR produces a heightened anxiety response in the elevated plus maze. These results suggest that the BTBR mouse is stressor-reactive exhibiting hormone responses that might predispose it to ASD.
ISSN:0166-4328
1872-7549
DOI:10.1016/j.bbr.2008.09.041