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Exaggerated responses to stress in the BTBR T+tf/J mouse: An unusual behavioral phenotype
This study shows that the BTBR T+tf/J mouse, a model for autism spectrum disorder (ASD), has increased levels of the stress hormone corticosterone, when compared to C57BL/6J mice. In addition, we have shown that tail suspension of the BTBR produces a heightened anxiety response in the elevated plus...
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| Published in: | Behavioural brain research 2009-02, Vol.197 (2), p.462-465 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c375t-f9b72c8160dd2253738ac2b8cf0f3f1666f5083142720fe5e3703f441b51dd633 |
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| cites | cdi_FETCH-LOGICAL-c375t-f9b72c8160dd2253738ac2b8cf0f3f1666f5083142720fe5e3703f441b51dd633 |
| container_end_page | 465 |
| container_issue | 2 |
| container_start_page | 462 |
| container_title | Behavioural brain research |
| container_volume | 197 |
| creator | Benno, Robert Smirnova, Yelena Vera, Susy Liggett, Amanda Schanz, Norman |
| description | This study shows that the BTBR T+tf/J mouse, a model for autism spectrum disorder (ASD), has increased levels of the stress hormone corticosterone, when compared to C57BL/6J mice. In addition, we have shown that tail suspension of the BTBR produces a heightened anxiety response in the elevated plus maze. These results suggest that the BTBR mouse is stressor-reactive exhibiting hormone responses that might predispose it to ASD. |
| doi_str_mv | 10.1016/j.bbr.2008.09.041 |
| format | article |
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| fulltext | fulltext |
| identifier | ISSN: 0166-4328 |
| ispartof | Behavioural brain research, 2009-02, Vol.197 (2), p.462-465 |
| issn | 0166-4328 1872-7549 |
| language | eng |
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| source | Elsevier:Jisc Collections:Elsevier Read and Publish Agreement 2022-2024:Freedom Collection (Reading list) |
| subjects | Animals Anxiety Anxiety - physiopathology Anxiety - psychology Autism spectrum disorder Autistic Disorder - genetics Autistic Disorder - physiopathology Autistic Disorder - psychology Behavior Behavioral psychophysiology Biological and medical sciences Blood corticosterone levels BTBR mouse Child clinical studies Corticosterone - blood Developmental disorders Disease Models, Animal Elevated plus maze Enzyme-Linked Immunosorbent Assay Exploratory Behavior - physiology Fundamental and applied biological sciences. Psychology Infantile autism Male Maze Learning - physiology Medical sciences Mice Mice, Inbred C57BL Mice, Inbred Strains Phenotype Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopathology. Psychiatry Stress, Physiological - physiology |
| title | Exaggerated responses to stress in the BTBR T+tf/J mouse: An unusual behavioral phenotype |
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