Characteristics of genetic epidemiology and genetic models for vitiligo

Vitiligo occurs with a frequency of 0.1% to 2% in various populations and is classified into several subtypes by its clinical presentation. Although genetic factors are thought to be involved in the cause of vitiligo, the genetic models for different phenotypes of vitiligo are unknown. Our purpose w...

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Bibliographic Details
Published in:Journal of the American Academy of Dermatology 2004-09, Vol.51 (3), p.383-390
Main Authors: Zhang, Xue-Jun, Liu, Jiang-Bo, Gui, Jin-Ping, Li, Ming, Xiong, Quan-Geng, Wu, Hong-Bo, Li, Jin-Xian, Yang, Sen, Wang, Hong-Yan, Gao, Min, Yang, Jie, Yang, Qing
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age of Onset
Asian Continental Ancestry Group - genetics
Biological and medical sciences
Child
Child, Preschool
China - epidemiology
Dermatology
Environment
Ethnic Groups - genetics
Genetic Predisposition to Disease
Humans
Infant
Medical sciences
Middle Aged
Models, Genetic
Multifactorial Inheritance
Phenotype
Pigmentary diseases of the skin
Risk
Surveys and Questionnaires
Vitiligo - classification
Vitiligo - epidemiology
Vitiligo - genetics
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Summary:Vitiligo occurs with a frequency of 0.1% to 2% in various populations and is classified into several subtypes by its clinical presentation. Although genetic factors are thought to be involved in the cause of vitiligo, the genetic models for different phenotypes of vitiligo are unknown. Our purpose was to explore potential genetic models for different phenotypes of vitiligo and analyze genetic epidemiologic characteristics of vitiligo in a Chinese population. Information from 2247 patients and members in their families was collected using a uniform questionnaire. Patients' clinical characteristics and their family history were analyzed using software. A complex segregation analysis was conducted to propose potential genetic models for vitiligo. Different subtypes of vitiligo had different ages of disease onset. In relatives of patients with vitiligo, the risk of developing vitiligo increased with increasing relatedness to the patients with vitiligo. A polygenic additive model was the best model for focal vitiligo, vitiligo vulgaris, acrofacial vitiligo, and segmental vitiligo with approximately 50% heritability in each. For universal vitiligo, the best model was an environmental model. This study indicated that different phenotypes of vitiligo had different pathogeneses and genetic backgrounds. Onset of vitiligo is possibly affected by both genetic backgrounds and common environmental factors.
ISSN:0190-9622
1097-6787
DOI:10.1016/j.jaad.2003.12.044