Multivariate analysis of clinical prognostic factors in children with intracranial ependymomas

• Published in: Journal of neuro-oncology 2004-07, Vol.68 (3), p.255-261
• Main Authors: JAING, Tang-Her, WANG, Huei-Shyong, TSAY, Pei-Kwei, TSENG, Chen-Kan, JUNG, Shih-Ming, LIN, Kuang-Lin, LUI, Tai-Ngar
• Format: Article
• Language: English
• Subjects: Adolescent; Age Factors; Biological and medical sciences; Child; Child, Preschool; Ependymoma - diagnosis; Ependymoma - mortality; Ependymoma - therapy; Female; Humans; Infant; Infratentorial Neoplasms - diagnosis; Infratentorial Neoplasms - mortality; Infratentorial Neoplasms - therapy; Male; Medical sciences; Multivariate Analysis; Neoplasm Recurrence, Local - diagnosis; Neoplasm Recurrence, Local - mortality; Neoplasm Recurrence, Local - therapy; Neurology; Prognosis; Retrospective Studies; Sex Factors; Supratentorial Neoplasms - diagnosis; Supratentorial Neoplasms - mortality; Supratentorial Neoplasms - therapy; Survival Analysis
• ISSN: 0167-594X; 1573-7373
• DOI: 10.1023/B:NEON.0000033383.84900.c1

The optimal postoperative management of pediatric intracranial ependymomas is controversial. We analyzed clinical prognostic factors for their influence on outcome in such children. Our retrospective series included 15 with supratentorial and 28 with infratentorial tumors. Twenty ependymomas were grade II, and 23 were anaplastic. Complete resection was performed in 18 patients, incomplete resection in 19, and stereotactic biopsy in 6. Radiotherapy was done in 31 patients and chemotherapy in 13. The surviving patients have been followed 8-232 months (median: 69 months). The median survival time was 30 months, and 5-year overall survival and progression-free survival rates were 53.9% and 45.9%, respectively. By tumor site: supratentorial, 56.6% and 50.9%; infratentorial, 52.3% and 42.5%. Multivariate analysis identified complete resection (5-year progression-free survival, 71.8%) and age