Screening of oxazepine indole enantiomers by means of high performance liquid chromatography with imprinted polymer stationary phase

Chromatographic enantiomer separations of different oxazepine indole derivatives were performed using a molecularly imprinted polymer. A 5aR,12R,13S‐trans‐6,6‐dimethyl‐12,13‐dihydro‐6H‐5a,13‐methanoindolo[2,1‐b][1,3]naphthoxazepine‐12‐carboxamide enantiomer derivative was used as a template and the...

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Bibliographic Details
Published in:Journal of separation science 2004-05, Vol.27 (7-8), p.547-551
Main Authors: Machtejevas, Egidijus, Sellergren, Börje, Martynaitis, Vytas, Owens, Paul K., Maruška, Audrius
Format: Article
Language:English
Subjects:
Analysis
Analytical biochemistry: general aspects, technics, instrumentation
Analytical chemistry
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Chemistry
Chromatographic methods and physical methods associated with chromatography
Chromatography
Chromatography, High Pressure Liquid - methods
Enantiomer separation
Exact sciences and technology
Fundamental and applied biological sciences. Psychology
General pharmacology
Indicators and Reagents
Medical sciences
Models, Molecular
Molecular imprinting
Oxazepine indole
Oxazepines - chemistry
Oxazepines - isolation & purification
Pharmacology. Drug treatments
Stereoisomerism
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Summary:Chromatographic enantiomer separations of different oxazepine indole derivatives were performed using a molecularly imprinted polymer. A 5aR,12R,13S‐trans‐6,6‐dimethyl‐12,13‐dihydro‐6H‐5a,13‐methanoindolo[2,1‐b][1,3]naphthoxazepine‐12‐carboxamide enantiomer derivative was used as a template and the resultant polymer has shown enantiomer recognition for series of template related compounds. The mechanistic description of the chiral discrimination process is scrutinised, comparing the discrimination between the different conformations and substituents of the oxazepine indoles.
ISSN:1615-9306
1615-9314
DOI:10.1002/jssc.200301675