P2X receptors and synaptic plasticity

Abstract Adenosine triphosphate (ATP) is released in many synapses in the CNS either together with other neurotransmitters, such as glutamate and GABA, or on its own. Postsynaptic action of ATP is mediated through metabotropic P2Y and ionotropic P2X receptors abundantly expressed in neural cells. Ac...

Full description

Saved in:
Bibliographic Details
Published in:Neuroscience 2009-01, Vol.158 (1), p.137-148
Main Authors: Pankratov, Y, Lalo, U, Krishtal, O.A, Verkhratsky, A
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - metabolism
Animals
ATP
Ca 2+ signaling
Calcium Signaling - physiology
Central Nervous System - metabolism
Central Nervous System - ultrastructure
Humans
LTD
LTP
Neurology
Neuronal Plasticity - physiology
P2X receptors
Receptors, Neurotransmitter - metabolism
Receptors, Purinergic P2 - metabolism
Receptors, Purinergic P2X
Synapses - metabolism
Synapses - ultrastructure
Synaptic Membranes - metabolism
Synaptic Membranes - ultrastructure
synaptic plasticity
Synaptic Transmission - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Adenosine triphosphate (ATP) is released in many synapses in the CNS either together with other neurotransmitters, such as glutamate and GABA, or on its own. Postsynaptic action of ATP is mediated through metabotropic P2Y and ionotropic P2X receptors abundantly expressed in neural cells. Activation of P2X receptors induces fast excitatory postsynaptic currents in synapses located in various brain regions, including medial habenula, hippocampus and cortex. P2X receptors display relatively high Ca2+ permeability and can mediate substantial Ca2+ influx at resting membrane potential. P2X receptors can dynamically interact with other neurotransmitter receptors, including N-methyl-D-aspartate (NMDA) receptors, GABAA receptors and nicotinic acetylcholine (ACh) receptors. Activation of P2X receptors has multiple modulatory effects on synaptic plasticity, either inhibiting or facilitating the long-term changes of synaptic strength depending on physiological context. At the same time precise mechanisms of P2X-dependent regulation of synaptic plasticity remain elusive. Further understanding of the role of P2X receptors in regulation of synaptic transmission in the CNS requires dissection of P2X-mediated effects on pre-synaptic terminals, postsynaptic membrane and glial cells.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2008.03.076