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The bradykinin B2 receptor in the early immune response against Listeria infection
The endogenous danger signal bradykinin was recently found implicated in the development of immunity against parasites via dendritic cells. We here report an essential role of the B 2 (B 2 R) bradykinin receptor in the early immune response against Listeria infection. Mice deficient in B 2 R (B 2 R...
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| Published in: | Medical microbiology and immunology 2009-02, Vol.198 (1), p.39-46 |
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| Main Authors: | , , , , |
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| container_end_page | 46 |
| container_issue | 1 |
| container_start_page | 39 |
| container_title | Medical microbiology and immunology |
| container_volume | 198 |
| creator | Kaman, Wendy E. Wolterink, Arthur F. W. M. Bader, Michael Boele, Linda C. L. van der Kleij, Desiree |
| description | The endogenous danger signal bradykinin was recently found implicated in the development of immunity against parasites via dendritic cells. We here report an essential role of the B
2
(B
2
R) bradykinin receptor in the early immune response against
Listeria
infection. Mice deficient in B
2
R (B
2
R
−/−
mice) were shown to suffer from increased hepatic bacterial burden and concomitant dramatic weight loss during infection with
Listeria monocytogenes
. Levels of cytokines known to play a pivotal role in the early phase immune response against
L. monocytogenes
, IL-12p70 and IFN-γ, were reduced in B
2
R
−/−
mice. To extend these findings to the human system, we show that bradykinin potentiates the production of IL-12p70 in human monocyte-derived dendritic cells
.
Thus, we show that bradykinin and the B
2
R play a role in early innate immune functions during bacterial infection. |
| doi_str_mv | 10.1007/s00430-008-0103-4 |
| format | article |
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2
(B
2
R) bradykinin receptor in the early immune response against
Listeria
infection. Mice deficient in B
2
R (B
2
R
−/−
mice) were shown to suffer from increased hepatic bacterial burden and concomitant dramatic weight loss during infection with
Listeria monocytogenes
. Levels of cytokines known to play a pivotal role in the early phase immune response against
L. monocytogenes
, IL-12p70 and IFN-γ, were reduced in B
2
R
−/−
mice. To extend these findings to the human system, we show that bradykinin potentiates the production of IL-12p70 in human monocyte-derived dendritic cells
.
Thus, we show that bradykinin and the B
2
R play a role in early innate immune functions during bacterial infection.</description><identifier>ISSN: 0300-8584</identifier><identifier>EISSN: 1432-1831</identifier><identifier>DOI: 10.1007/s00430-008-0103-4</identifier><identifier>PMID: 18810490</identifier><identifier>CODEN: MMIYAO</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Animals ; Bacteria ; Bacteriology ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Body Weight ; Bradykinin - immunology ; Cells, Cultured ; Cytokines ; Cytokines - secretion ; Dendritic Cells - immunology ; Fundamental and applied biological sciences. Psychology ; Humans ; Immune system ; Immunology ; Infectious diseases ; Interferon-gamma - secretion ; Interleukin-12 - biosynthesis ; Listeria monocytogenes ; Listeria monocytogenes - immunology ; Listeriosis - immunology ; Liver - microbiology ; Medical Microbiology ; Mice ; Mice, Knockout ; Microbiology ; Miscellaneous ; Original Investigation ; Peptides ; Receptor, Bradykinin B2 - deficiency ; Receptor, Bradykinin B2 - immunology ; Rodents ; Virology</subject><ispartof>Medical microbiology and immunology, 2009-02, Vol.198 (1), p.39-46</ispartof><rights>Springer-Verlag 2008</rights><rights>2009 INIST-CNRS</rights><rights>Springer-Verlag 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-a6bb7e1646fc6383b06fdb671c78cdd1038467b3b0038e2c6be3681b19dfe8383</citedby><cites>FETCH-LOGICAL-c430t-a6bb7e1646fc6383b06fdb671c78cdd1038467b3b0038e2c6be3681b19dfe8383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21062051$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18810490$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaman, Wendy E.</creatorcontrib><creatorcontrib>Wolterink, Arthur F. W. M.</creatorcontrib><creatorcontrib>Bader, Michael</creatorcontrib><creatorcontrib>Boele, Linda C. L.</creatorcontrib><creatorcontrib>van der Kleij, Desiree</creatorcontrib><title>The bradykinin B2 receptor in the early immune response against Listeria infection</title><title>Medical microbiology and immunology</title><addtitle>Med Microbiol Immunol</addtitle><addtitle>Med Microbiol Immunol</addtitle><description>The endogenous danger signal bradykinin was recently found implicated in the development of immunity against parasites via dendritic cells. We here report an essential role of the B
2
(B
2
R) bradykinin receptor in the early immune response against
Listeria
infection. Mice deficient in B
2
R (B
2
R
−/−
mice) were shown to suffer from increased hepatic bacterial burden and concomitant dramatic weight loss during infection with
Listeria monocytogenes
. Levels of cytokines known to play a pivotal role in the early phase immune response against
L. monocytogenes
, IL-12p70 and IFN-γ, were reduced in B
2
R
−/−
mice. To extend these findings to the human system, we show that bradykinin potentiates the production of IL-12p70 in human monocyte-derived dendritic cells
.
Thus, we show that bradykinin and the B
2
R play a role in early innate immune functions during bacterial infection.</description><subject>Animals</subject><subject>Bacteria</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Body Weight</subject><subject>Bradykinin - immunology</subject><subject>Cells, Cultured</subject><subject>Cytokines</subject><subject>Cytokines - secretion</subject><subject>Dendritic Cells - immunology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immunology</subject><subject>Infectious diseases</subject><subject>Interferon-gamma - secretion</subject><subject>Interleukin-12 - biosynthesis</subject><subject>Listeria monocytogenes</subject><subject>Listeria monocytogenes - immunology</subject><subject>Listeriosis - immunology</subject><subject>Liver - microbiology</subject><subject>Medical Microbiology</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Original Investigation</subject><subject>Peptides</subject><subject>Receptor, Bradykinin B2 - deficiency</subject><subject>Receptor, Bradykinin B2 - immunology</subject><subject>Rodents</subject><subject>Virology</subject><issn>0300-8584</issn><issn>1432-1831</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNqFkU2LFDEQhoMo7rj6A7xII-ittSrJpDNHXfyCAUHWc0jS1WvW7vSYdB_m31vLDC4I4ikf71NvqvIK8RzhDQJ0byuAVtAC2BYQVKsfiA1qJVu0Ch-KDSiA1m6tvhBPar0FwM5IeCwu0FoEvYON-Hb9g5pQfH_8mXLKzXvZFIp0WObS8HFhlXwZj02apjUTi_Uw50qNv_Ep16XZp7pQSZ7pgeKS5vxUPBr8WOnZeb0U3z9-uL763O6_fvpy9W7fRm56ab0JoSM02gzRKKsCmKEPpsPY2dj3PI_Vpgt8zzuS0QRSxmLAXT-Q5YJL8frkeyjzr5Xq4qZUI42jzzSv1Rlj5U7b_4MStmDZm8GXf4G381oyD-GkBP5IC4ohPEGxzLUWGtyhpMmXo0Nwd7G4UyyOY3F3sTjNNS_OxmuYqL-vOOfAwKsz4Gv041B8jqn-4SQCB7dF5uSJqyzlGyr3Hf779d95UaNE</recordid><startdate>20090201</startdate><enddate>20090201</enddate><creator>Kaman, Wendy E.</creator><creator>Wolterink, Arthur F. W. M.</creator><creator>Bader, Michael</creator><creator>Boele, Linda C. L.</creator><creator>van der Kleij, Desiree</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7QL</scope><scope>7T7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20090201</creationdate><title>The bradykinin B2 receptor in the early immune response against Listeria infection</title><author>Kaman, Wendy E. ; Wolterink, Arthur F. W. M. ; Bader, Michael ; Boele, Linda C. L. ; van der Kleij, Desiree</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-a6bb7e1646fc6383b06fdb671c78cdd1038467b3b0038e2c6be3681b19dfe8383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Bacteria</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Body Weight</topic><topic>Bradykinin - immunology</topic><topic>Cells, Cultured</topic><topic>Cytokines</topic><topic>Cytokines - secretion</topic><topic>Dendritic Cells - immunology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Immune system</topic><topic>Immunology</topic><topic>Infectious diseases</topic><topic>Interferon-gamma - secretion</topic><topic>Interleukin-12 - biosynthesis</topic><topic>Listeria monocytogenes</topic><topic>Listeria monocytogenes - immunology</topic><topic>Listeriosis - immunology</topic><topic>Liver - microbiology</topic><topic>Medical Microbiology</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Original Investigation</topic><topic>Peptides</topic><topic>Receptor, Bradykinin B2 - deficiency</topic><topic>Receptor, Bradykinin B2 - immunology</topic><topic>Rodents</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaman, Wendy E.</creatorcontrib><creatorcontrib>Wolterink, Arthur F. W. M.</creatorcontrib><creatorcontrib>Bader, Michael</creatorcontrib><creatorcontrib>Boele, Linda C. 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W. M.</au><au>Bader, Michael</au><au>Boele, Linda C. L.</au><au>van der Kleij, Desiree</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The bradykinin B2 receptor in the early immune response against Listeria infection</atitle><jtitle>Medical microbiology and immunology</jtitle><stitle>Med Microbiol Immunol</stitle><addtitle>Med Microbiol Immunol</addtitle><date>2009-02-01</date><risdate>2009</risdate><volume>198</volume><issue>1</issue><spage>39</spage><epage>46</epage><pages>39-46</pages><issn>0300-8584</issn><eissn>1432-1831</eissn><coden>MMIYAO</coden><abstract>The endogenous danger signal bradykinin was recently found implicated in the development of immunity against parasites via dendritic cells. We here report an essential role of the B
2
(B
2
R) bradykinin receptor in the early immune response against
Listeria
infection. Mice deficient in B
2
R (B
2
R
−/−
mice) were shown to suffer from increased hepatic bacterial burden and concomitant dramatic weight loss during infection with
Listeria monocytogenes
. Levels of cytokines known to play a pivotal role in the early phase immune response against
L. monocytogenes
, IL-12p70 and IFN-γ, were reduced in B
2
R
−/−
mice. To extend these findings to the human system, we show that bradykinin potentiates the production of IL-12p70 in human monocyte-derived dendritic cells
.
Thus, we show that bradykinin and the B
2
R play a role in early innate immune functions during bacterial infection.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>18810490</pmid><doi>10.1007/s00430-008-0103-4</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-8584 |
| ispartof | Medical microbiology and immunology, 2009-02, Vol.198 (1), p.39-46 |
| issn | 0300-8584 1432-1831 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_66829488 |
| source | Springer Nature |
| subjects | Animals Bacteria Bacteriology Biological and medical sciences Biomedical and Life Sciences Biomedicine Body Weight Bradykinin - immunology Cells, Cultured Cytokines Cytokines - secretion Dendritic Cells - immunology Fundamental and applied biological sciences. Psychology Humans Immune system Immunology Infectious diseases Interferon-gamma - secretion Interleukin-12 - biosynthesis Listeria monocytogenes Listeria monocytogenes - immunology Listeriosis - immunology Liver - microbiology Medical Microbiology Mice Mice, Knockout Microbiology Miscellaneous Original Investigation Peptides Receptor, Bradykinin B2 - deficiency Receptor, Bradykinin B2 - immunology Rodents Virology |
| title | The bradykinin B2 receptor in the early immune response against Listeria infection |
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