1-Phenyl-3-toluyl-4-[ ortho-1′-( N-ethyl-2′-methylpropylamine)]phenylpyrazole, synthesis and evaluation of the in vitro antifungal activity against Botrytis cinerea and Fusarium oxysporum

A novel antifungal pyrazole derivative was synthesized. Designated 1-phenyl-3-toluyl-4-[ ortho-1′-( N-ethyl-2′-methylpropylamine)]phenylpyrazole, the compound exerted an antifungal effect toward Botrytis cinerea and Fusarium oxysporum. In fact, our results clearly show that mycelial growth and conid...

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Bibliographic Details
Published in:Farmaco (Società chimica italiana : 1989) 2004-09, Vol.59 (9), p.673-678
Main Authors: Dardari, Zainaba, Boudouma, Mohammed, Sebban, Abdelfatah, Bahloul, Abdelmejid, Kitane, Said, Berrada, Mohamed
Format: Article
Language:English
Subjects:
1-Phenyl-3-toluyl-4-[ ortho-1′-( N-ethyl-2′-methylpropylamine)]phenylpyrazole
Antifungal
Antifungal Agents - chemical synthesis
Antifungal Agents - pharmacology
Botrytis - drug effects
Botrytis - growth & development
Botrytis cinerea
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Fusarium - drug effects
Fusarium - growth & development
Fusarium oxysporum
Pyrazoles - chemical synthesis
Pyrazoles - pharmacology
Synthesis
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Summary:A novel antifungal pyrazole derivative was synthesized. Designated 1-phenyl-3-toluyl-4-[ ortho-1′-( N-ethyl-2′-methylpropylamine)]phenylpyrazole, the compound exerted an antifungal effect toward Botrytis cinerea and Fusarium oxysporum. In fact, our results clearly show that mycelial growth and conidial germination of both fungi were blocked by the compound. Indeed, a 96-well microbioassay procedure was used for fast and easy evaluation of minimal inhibitory concentration (MIC). The MIC values for B. cinerea and F. oxysporum were 25 and 36 μg/ml, respectively.
ISSN:0014-827X
1879-0569
DOI:10.1016/j.farmac.2004.04.009