Tumour biological aspects of CD24, a mucin-like adhesion molecule

CD24 is a molecule that recently has raised considerable attention in tumour biology. It is involved in cell adhesion and metastatic tumour spread. It has also been described as a new diagnostic marker of tumours, of neuroendocrine differentiation and, possibly most intriguing of all, of patient pro...

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Bibliographic Details
Published in:Journal of molecular histology 2004-03, Vol.35 (3), p.255-262
Main Authors: Kristiansen, G, Sammar, M, Altevogt, P
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Antigens, CD - metabolism
Biomarkers, Tumor - metabolism
Cancer
CD24 Antigen
Cell Adhesion
Cell Adhesion Molecules - metabolism
Female
Humans
Immunohistochemistry
Male
Membrane Glycoproteins - metabolism
Molecular Sequence Data
Mucins - metabolism
Multivariate analysis
Neoplasm Metastasis
Neoplasms - metabolism
Neoplasms - pathology
Pancreatic cancer
Prognosis
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Summary:CD24 is a molecule that recently has raised considerable attention in tumour biology. It is involved in cell adhesion and metastatic tumour spread. It has also been described as a new diagnostic marker of tumours, of neuroendocrine differentiation and, possibly most intriguing of all, of patient prognosis. High rates of CD24 expression detected by immunohistochemistry have been found in epithelial ovarian cancer (83%), breast cancer (85%), non-small cell lung cancer (45%), prostate cancer (48%) and pancreatic cancer (72%). With the exception of pancreatic cancer, high rates of CD24 are significantly associated with a more aggressive course of the disease, a finding that remains significant in a multivariate analysis. The aim of this review is to summarize relevant work covering these aspects of CD24.
ISSN:1567-2379
1567-2387
DOI:10.1023/B:HIJO.0000032357.16261.c5