Burden of Illness in Cancer Survivors: Findings From a Population-Based National Sample

Background: Population trends in aging and improved cancer survival are likely to result in increased cancer prevalence in the United States, but few estimates of the burden of illness among cancer survivors are currently available. The purpose of this study was to estimate the burden of illness in...

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Published in:JNCI : Journal of the National Cancer Institute 2004-09, Vol.96 (17), p.1322-1330
Main Authors: Yabroff, K. Robin, Lawrence, William F., Clauser, Steven, Davis, William W., Brown, Martin L.
Format: Article
Language:English
Subjects:
Activities of Daily Living
Adult
Age Distribution
Aged
Biological and medical sciences
Cancer
Case-Control Studies
Cost of Illness
Educational Status
Efficiency
Female
Health Status
Health Status Indicators
Humans
Incidence
Male
Medical sciences
Medical treatment
Middle Aged
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Neoplasms - epidemiology
Prevalence
Quality of Life
Sex Distribution
Surveys and Questionnaires
Survivors - statistics & numerical data
Tumors
United States - epidemiology
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container_issue 17
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creator Yabroff, K. Robin
Lawrence, William F.
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description Background: Population trends in aging and improved cancer survival are likely to result in increased cancer prevalence in the United States, but few estimates of the burden of illness among cancer survivors are currently available. The purpose of this study was to estimate the burden of illness in cancer survivors in a national, population-based sample. Methods: A total of 1823 cancer survivors and 5469 age-, sex-, and educational attainment–matched control subjects were identified from the 2000 National Health Interview Survey. Multiple measures of burden, including utility, a summary measure of health, and days lost from work, were compared using two-sided tests of statistical significance for the two groups overall and for subgroups stratified by tumor site and time since diagnosis. Results: Compared with matched control subjects, cancer survivors had poorer outcomes across all burden measures (P
doi_str_mv 10.1093/jnci/djh255
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Robin ; Lawrence, William F. ; Clauser, Steven ; Davis, William W. ; Brown, Martin L.</creator><creatorcontrib>Yabroff, K. Robin ; Lawrence, William F. ; Clauser, Steven ; Davis, William W. ; Brown, Martin L.</creatorcontrib><description>Background: Population trends in aging and improved cancer survival are likely to result in increased cancer prevalence in the United States, but few estimates of the burden of illness among cancer survivors are currently available. The purpose of this study was to estimate the burden of illness in cancer survivors in a national, population-based sample. Methods: A total of 1823 cancer survivors and 5469 age-, sex-, and educational attainment–matched control subjects were identified from the 2000 National Health Interview Survey. Multiple measures of burden, including utility, a summary measure of health, and days lost from work, were compared using two-sided tests of statistical significance for the two groups overall and for subgroups stratified by tumor site and time since diagnosis. Results: Compared with matched control subjects, cancer survivors had poorer outcomes across all burden measures (P&lt;.01). Cancer survivors had lower utility values (0.74 versus 0.80; P&lt;.001) and higher levels of lost productivity and were more likely to report their health as fair or poor (31.0% versus 17.9%; P&lt;.001) than matched control subjects. Cancer survivors reported statistically significantly higher burden than did control subjects across tumor sites and across time since diagnosis (i.e., within the past year, 2–5 years, 6–10 years, and ≥11 years for the majority of measures. Conclusions: Cancer survivors have poorer health outcomes than do similar individuals without cancer across multiple burden measures. These decrements are consistent across tumor sites and are found in patients many years following reported diagnosis. Improved measurement of long-term burden of illness will be important for future prospective research.</description><identifier>ISSN: 0027-8874</identifier><identifier>EISSN: 1460-2105</identifier><identifier>DOI: 10.1093/jnci/djh255</identifier><identifier>PMID: 15339970</identifier><identifier>CODEN: JNCIEQ</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Activities of Daily Living ; Adult ; Age Distribution ; Aged ; Biological and medical sciences ; Cancer ; Case-Control Studies ; Cost of Illness ; Educational Status ; Efficiency ; Female ; Health Status ; Health Status Indicators ; Humans ; Incidence ; Male ; Medical sciences ; Medical treatment ; Middle Aged ; Multiple tumors. Solid tumors. 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Robin</creatorcontrib><creatorcontrib>Lawrence, William F.</creatorcontrib><creatorcontrib>Clauser, Steven</creatorcontrib><creatorcontrib>Davis, William W.</creatorcontrib><creatorcontrib>Brown, Martin L.</creatorcontrib><title>Burden of Illness in Cancer Survivors: Findings From a Population-Based National Sample</title><title>JNCI : Journal of the National Cancer Institute</title><addtitle>JNCI J Natl Cancer Inst</addtitle><description>Background: Population trends in aging and improved cancer survival are likely to result in increased cancer prevalence in the United States, but few estimates of the burden of illness among cancer survivors are currently available. The purpose of this study was to estimate the burden of illness in cancer survivors in a national, population-based sample. Methods: A total of 1823 cancer survivors and 5469 age-, sex-, and educational attainment–matched control subjects were identified from the 2000 National Health Interview Survey. Multiple measures of burden, including utility, a summary measure of health, and days lost from work, were compared using two-sided tests of statistical significance for the two groups overall and for subgroups stratified by tumor site and time since diagnosis. Results: Compared with matched control subjects, cancer survivors had poorer outcomes across all burden measures (P&lt;.01). Cancer survivors had lower utility values (0.74 versus 0.80; P&lt;.001) and higher levels of lost productivity and were more likely to report their health as fair or poor (31.0% versus 17.9%; P&lt;.001) than matched control subjects. Cancer survivors reported statistically significantly higher burden than did control subjects across tumor sites and across time since diagnosis (i.e., within the past year, 2–5 years, 6–10 years, and ≥11 years for the majority of measures. Conclusions: Cancer survivors have poorer health outcomes than do similar individuals without cancer across multiple burden measures. These decrements are consistent across tumor sites and are found in patients many years following reported diagnosis. Improved measurement of long-term burden of illness will be important for future prospective research.</description><subject>Activities of Daily Living</subject><subject>Adult</subject><subject>Age Distribution</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>Case-Control Studies</subject><subject>Cost of Illness</subject><subject>Educational Status</subject><subject>Efficiency</subject><subject>Female</subject><subject>Health Status</subject><subject>Health Status Indicators</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medical treatment</subject><subject>Middle Aged</subject><subject>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</subject><subject>Neoplasms - epidemiology</subject><subject>Prevalence</subject><subject>Quality of Life</subject><subject>Sex Distribution</subject><subject>Surveys and Questionnaires</subject><subject>Survivors - statistics &amp; numerical data</subject><subject>Tumors</subject><subject>United States - epidemiology</subject><issn>0027-8874</issn><issn>1460-2105</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNpd0M9rFDEUwPEgil2rJ-8SBL3I2PzOxJtdXFssWlpF8RIykzeaNZOsyU7R_95Zd7FgLiHkw-PxRegxJS8pMfxknfpw4tffmZR30IIKRRpGibyLFoQw3bStFkfoQa1rMh_DxH10RCXnxmiyQJ9Pp-Ih4Tzg8xgT1IpDwkuXeij4eio34SaX-gqvQvIhfat4VfKIHb7Mmym6bcipOXUVPH7_9-EivnbjJsJDdG9wscKjw32MPq3efFyeNRcf3p4vX180vWj5thmc75h0nrXaCQDDOmYo6ZUH5YRRmncgO6l7YbjmfugIUCmJcVQbMgBR_Bg938_dlPxzgrq1Y6g9xOgS5KlapVrOFGUzfPofXOepzAtXyxgxrZBSzujFHvUl11pgsJsSRld-W0rsLrbdxbb72LN-chg5dSP4W3uoO4NnB-Bq7-JQ5qyh3jolONNmt1uzd6Fu4de_f1d-2DmBlvbsy1errt5d6tWVtEv-B8BKlrA</recordid><startdate>20040901</startdate><enddate>20040901</enddate><creator>Yabroff, K. 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identifier ISSN: 0027-8874
ispartof JNCI : Journal of the National Cancer Institute, 2004-09, Vol.96 (17), p.1322-1330
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source Oxford Journals Online
subjects Activities of Daily Living
Adult
Age Distribution
Aged
Biological and medical sciences
Cancer
Case-Control Studies
Cost of Illness
Educational Status
Efficiency
Female
Health Status
Health Status Indicators
Humans
Incidence
Male
Medical sciences
Medical treatment
Middle Aged
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Neoplasms - epidemiology
Prevalence
Quality of Life
Sex Distribution
Surveys and Questionnaires
Survivors - statistics & numerical data
Tumors
United States - epidemiology
title Burden of Illness in Cancer Survivors: Findings From a Population-Based National Sample
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