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A multitechnique evaluation of topical corticosteroid treatment
Background/purpose: Cortiscosteroids are widely prescribed for systemic or local treatment of inflammatory autoimmune disorders. Long‐term therapy is associated with side effects and causes cutaneous atrophy of the epidermis and the dermis. The present study aims to evaluate with several noninvasive...
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Published in: | Skin research and technology 2009-02, Vol.15 (1), p.35-39 |
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creator | Josse, G. Rouvrais, C. Mas, A. Haftek, M. Delalleau, A. Ferraq, Y. Ossant, F. George, J. Lagarde, J. M. Schmitt, A. M. |
description | Background/purpose: Cortiscosteroids are widely prescribed for systemic or local treatment of inflammatory autoimmune disorders. Long‐term therapy is associated with side effects and causes cutaneous atrophy of the epidermis and the dermis. The present study aims to evaluate with several noninvasive techniques, the skin modifications observed during cortiscosteroids treatment. The potential of skin mechanical measurement and ultrasound radio frequency (RF) signal analysis are proposed as new measures more closely related to the functional impairments.
Methods: Thirteen young healthy women volunteers had two applications per day on one arm of topical Clobetasol propionate 0.05% for 28 days, and they were followed for 28 days more. Skin modifications were studied by high‐frequency ultrasound imaging, ultrasound RF signal analysis, optical coherence tomography and by the suction test.
Results: For all the techniques, a statistically significant change is observed with treatment. Large variations, around 30%, are observed for all techniques, but less for ultrasound imaging (10%). Dermis and epidermis thickness presented stable measurements on the nontreated zone. At the end of the study, measures returned to normal. The dynamic is mainly observed within the first 14 days of treatment and within the first 14 days after its cessation.
Conclusion: Similar dynamics of skin modification during cortiscosteroid treatment was observed with very different techniques. Moreover, the potential of RF ultrasound analysis and mechanical skin measurement for characterizing skin structural and functional impairments has been evaluated. |
doi_str_mv | 10.1111/j.1600-0846.2008.00326.x |
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fullrecord | <record><control><sourceid>proquest_24P</sourceid><recordid>TN_cdi_proquest_miscellaneous_66833229</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>66833229</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4046-8f2d1e1048053acf0982e4e23c445c09314e3e8776993517c11357cc8e53a6de3</originalsourceid><addsrcrecordid>eNqNkNFuFCEUQImxsWv1F8w8-TbjBQYGkiamNra1adqkrdm-EWTvRLYzywqMbv9etrupr_ICCedcyCGkotDQsj4tGyoBalCtbBiAagA4k83mFZm9XLwmM9Cg606wh0PyNqUlAAhN-RtySDUVTHRyRj6fVOM0ZJ_R_Vz5XxNW-NsOk80-rKrQVzmsvbND5ULM3oWUMQa_qHJEm0dc5XfkoLdDwvf7_Yh8P_t6f3pRX92cfzs9uapdC62sVc8WFCm0CgS3rgetGLbIuGtb4UBz2iJH1XVSay5o5yjlonNOYcHlAvkR-bibu46h_DJlM_rkcBjsCsOUjJSKc8Z0AdUOdDGkFLE36-hHG58MBbONZ5Zm28hsG5ltPPMcz2yK-mH_xvRjxMU_cV-rAMc74I8f8Om_B5u72_tyKHq9033JuHnRbXw0suOdMPPrc3Mxvzy7m8-_mAf-FwS-jEg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>66833229</pqid></control><display><type>article</type><title>A multitechnique evaluation of topical corticosteroid treatment</title><source>Wiley Online Library website</source><creator>Josse, G. ; Rouvrais, C. ; Mas, A. ; Haftek, M. ; Delalleau, A. ; Ferraq, Y. ; Ossant, F. ; George, J. ; Lagarde, J. M. ; Schmitt, A. M.</creator><creatorcontrib>Josse, G. ; Rouvrais, C. ; Mas, A. ; Haftek, M. ; Delalleau, A. ; Ferraq, Y. ; Ossant, F. ; George, J. ; Lagarde, J. M. ; Schmitt, A. M.</creatorcontrib><description>Background/purpose: Cortiscosteroids are widely prescribed for systemic or local treatment of inflammatory autoimmune disorders. Long‐term therapy is associated with side effects and causes cutaneous atrophy of the epidermis and the dermis. The present study aims to evaluate with several noninvasive techniques, the skin modifications observed during cortiscosteroids treatment. The potential of skin mechanical measurement and ultrasound radio frequency (RF) signal analysis are proposed as new measures more closely related to the functional impairments.
Methods: Thirteen young healthy women volunteers had two applications per day on one arm of topical Clobetasol propionate 0.05% for 28 days, and they were followed for 28 days more. Skin modifications were studied by high‐frequency ultrasound imaging, ultrasound RF signal analysis, optical coherence tomography and by the suction test.
Results: For all the techniques, a statistically significant change is observed with treatment. Large variations, around 30%, are observed for all techniques, but less for ultrasound imaging (10%). Dermis and epidermis thickness presented stable measurements on the nontreated zone. At the end of the study, measures returned to normal. The dynamic is mainly observed within the first 14 days of treatment and within the first 14 days after its cessation.
Conclusion: Similar dynamics of skin modification during cortiscosteroid treatment was observed with very different techniques. Moreover, the potential of RF ultrasound analysis and mechanical skin measurement for characterizing skin structural and functional impairments has been evaluated.</description><identifier>ISSN: 0909-752X</identifier><identifier>EISSN: 1600-0846</identifier><identifier>DOI: 10.1111/j.1600-0846.2008.00326.x</identifier><identifier>PMID: 19152576</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Administration, Topical ; Adolescent ; Adrenal Cortex Hormones - administration & dosage ; Adult ; Clobetasol - administration & dosage ; corticosteroid ; Elasticity Imaging Techniques - methods ; Female ; Humans ; mechanical properties ; optical coherence tomography (OCT) ; Reproducibility of Results ; Sensitivity and Specificity ; skin ; Skin - cytology ; Skin - drug effects ; Skin Physiological Phenomena - drug effects ; Skin Tests - methods ; Suction ; Tomography, Optical Coherence - methods ; ultrasound imaging (UBM) ; Young Adult</subject><ispartof>Skin research and technology, 2009-02, Vol.15 (1), p.35-39</ispartof><rights>2008 The Authors. Journal compilation © 2008 Blackwell Munksgaard</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4046-8f2d1e1048053acf0982e4e23c445c09314e3e8776993517c11357cc8e53a6de3</citedby><cites>FETCH-LOGICAL-c4046-8f2d1e1048053acf0982e4e23c445c09314e3e8776993517c11357cc8e53a6de3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0846.2008.00326.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0846.2008.00326.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,11562,27924,27925,46052,46476</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1600-0846.2008.00326.x$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19152576$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Josse, G.</creatorcontrib><creatorcontrib>Rouvrais, C.</creatorcontrib><creatorcontrib>Mas, A.</creatorcontrib><creatorcontrib>Haftek, M.</creatorcontrib><creatorcontrib>Delalleau, A.</creatorcontrib><creatorcontrib>Ferraq, Y.</creatorcontrib><creatorcontrib>Ossant, F.</creatorcontrib><creatorcontrib>George, J.</creatorcontrib><creatorcontrib>Lagarde, J. M.</creatorcontrib><creatorcontrib>Schmitt, A. M.</creatorcontrib><title>A multitechnique evaluation of topical corticosteroid treatment</title><title>Skin research and technology</title><addtitle>Skin Res Technol</addtitle><description>Background/purpose: Cortiscosteroids are widely prescribed for systemic or local treatment of inflammatory autoimmune disorders. Long‐term therapy is associated with side effects and causes cutaneous atrophy of the epidermis and the dermis. The present study aims to evaluate with several noninvasive techniques, the skin modifications observed during cortiscosteroids treatment. The potential of skin mechanical measurement and ultrasound radio frequency (RF) signal analysis are proposed as new measures more closely related to the functional impairments.
Methods: Thirteen young healthy women volunteers had two applications per day on one arm of topical Clobetasol propionate 0.05% for 28 days, and they were followed for 28 days more. Skin modifications were studied by high‐frequency ultrasound imaging, ultrasound RF signal analysis, optical coherence tomography and by the suction test.
Results: For all the techniques, a statistically significant change is observed with treatment. Large variations, around 30%, are observed for all techniques, but less for ultrasound imaging (10%). Dermis and epidermis thickness presented stable measurements on the nontreated zone. At the end of the study, measures returned to normal. The dynamic is mainly observed within the first 14 days of treatment and within the first 14 days after its cessation.
Conclusion: Similar dynamics of skin modification during cortiscosteroid treatment was observed with very different techniques. Moreover, the potential of RF ultrasound analysis and mechanical skin measurement for characterizing skin structural and functional impairments has been evaluated.</description><subject>Administration, Topical</subject><subject>Adolescent</subject><subject>Adrenal Cortex Hormones - administration & dosage</subject><subject>Adult</subject><subject>Clobetasol - administration & dosage</subject><subject>corticosteroid</subject><subject>Elasticity Imaging Techniques - methods</subject><subject>Female</subject><subject>Humans</subject><subject>mechanical properties</subject><subject>optical coherence tomography (OCT)</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>skin</subject><subject>Skin - cytology</subject><subject>Skin - drug effects</subject><subject>Skin Physiological Phenomena - drug effects</subject><subject>Skin Tests - methods</subject><subject>Suction</subject><subject>Tomography, Optical Coherence - methods</subject><subject>ultrasound imaging (UBM)</subject><subject>Young Adult</subject><issn>0909-752X</issn><issn>1600-0846</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNqNkNFuFCEUQImxsWv1F8w8-TbjBQYGkiamNra1adqkrdm-EWTvRLYzywqMbv9etrupr_ICCedcyCGkotDQsj4tGyoBalCtbBiAagA4k83mFZm9XLwmM9Cg606wh0PyNqUlAAhN-RtySDUVTHRyRj6fVOM0ZJ_R_Vz5XxNW-NsOk80-rKrQVzmsvbND5ULM3oWUMQa_qHJEm0dc5XfkoLdDwvf7_Yh8P_t6f3pRX92cfzs9uapdC62sVc8WFCm0CgS3rgetGLbIuGtb4UBz2iJH1XVSay5o5yjlonNOYcHlAvkR-bibu46h_DJlM_rkcBjsCsOUjJSKc8Z0AdUOdDGkFLE36-hHG58MBbONZ5Zm28hsG5ltPPMcz2yK-mH_xvRjxMU_cV-rAMc74I8f8Om_B5u72_tyKHq9033JuHnRbXw0suOdMPPrc3Mxvzy7m8-_mAf-FwS-jEg</recordid><startdate>200902</startdate><enddate>200902</enddate><creator>Josse, G.</creator><creator>Rouvrais, C.</creator><creator>Mas, A.</creator><creator>Haftek, M.</creator><creator>Delalleau, A.</creator><creator>Ferraq, Y.</creator><creator>Ossant, F.</creator><creator>George, J.</creator><creator>Lagarde, J. M.</creator><creator>Schmitt, A. M.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200902</creationdate><title>A multitechnique evaluation of topical corticosteroid treatment</title><author>Josse, G. ; Rouvrais, C. ; Mas, A. ; Haftek, M. ; Delalleau, A. ; Ferraq, Y. ; Ossant, F. ; George, J. ; Lagarde, J. M. ; Schmitt, A. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4046-8f2d1e1048053acf0982e4e23c445c09314e3e8776993517c11357cc8e53a6de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Administration, Topical</topic><topic>Adolescent</topic><topic>Adrenal Cortex Hormones - administration & dosage</topic><topic>Adult</topic><topic>Clobetasol - administration & dosage</topic><topic>corticosteroid</topic><topic>Elasticity Imaging Techniques - methods</topic><topic>Female</topic><topic>Humans</topic><topic>mechanical properties</topic><topic>optical coherence tomography (OCT)</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>skin</topic><topic>Skin - cytology</topic><topic>Skin - drug effects</topic><topic>Skin Physiological Phenomena - drug effects</topic><topic>Skin Tests - methods</topic><topic>Suction</topic><topic>Tomography, Optical Coherence - methods</topic><topic>ultrasound imaging (UBM)</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Josse, G.</creatorcontrib><creatorcontrib>Rouvrais, C.</creatorcontrib><creatorcontrib>Mas, A.</creatorcontrib><creatorcontrib>Haftek, M.</creatorcontrib><creatorcontrib>Delalleau, A.</creatorcontrib><creatorcontrib>Ferraq, Y.</creatorcontrib><creatorcontrib>Ossant, F.</creatorcontrib><creatorcontrib>George, J.</creatorcontrib><creatorcontrib>Lagarde, J. M.</creatorcontrib><creatorcontrib>Schmitt, A. M.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Skin research and technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Josse, G.</au><au>Rouvrais, C.</au><au>Mas, A.</au><au>Haftek, M.</au><au>Delalleau, A.</au><au>Ferraq, Y.</au><au>Ossant, F.</au><au>George, J.</au><au>Lagarde, J. M.</au><au>Schmitt, A. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A multitechnique evaluation of topical corticosteroid treatment</atitle><jtitle>Skin research and technology</jtitle><addtitle>Skin Res Technol</addtitle><date>2009-02</date><risdate>2009</risdate><volume>15</volume><issue>1</issue><spage>35</spage><epage>39</epage><pages>35-39</pages><issn>0909-752X</issn><eissn>1600-0846</eissn><abstract>Background/purpose: Cortiscosteroids are widely prescribed for systemic or local treatment of inflammatory autoimmune disorders. Long‐term therapy is associated with side effects and causes cutaneous atrophy of the epidermis and the dermis. The present study aims to evaluate with several noninvasive techniques, the skin modifications observed during cortiscosteroids treatment. The potential of skin mechanical measurement and ultrasound radio frequency (RF) signal analysis are proposed as new measures more closely related to the functional impairments.
Methods: Thirteen young healthy women volunteers had two applications per day on one arm of topical Clobetasol propionate 0.05% for 28 days, and they were followed for 28 days more. Skin modifications were studied by high‐frequency ultrasound imaging, ultrasound RF signal analysis, optical coherence tomography and by the suction test.
Results: For all the techniques, a statistically significant change is observed with treatment. Large variations, around 30%, are observed for all techniques, but less for ultrasound imaging (10%). Dermis and epidermis thickness presented stable measurements on the nontreated zone. At the end of the study, measures returned to normal. The dynamic is mainly observed within the first 14 days of treatment and within the first 14 days after its cessation.
Conclusion: Similar dynamics of skin modification during cortiscosteroid treatment was observed with very different techniques. Moreover, the potential of RF ultrasound analysis and mechanical skin measurement for characterizing skin structural and functional impairments has been evaluated.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19152576</pmid><doi>10.1111/j.1600-0846.2008.00326.x</doi><tpages>5</tpages></addata></record> |
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subjects | Administration, Topical Adolescent Adrenal Cortex Hormones - administration & dosage Adult Clobetasol - administration & dosage corticosteroid Elasticity Imaging Techniques - methods Female Humans mechanical properties optical coherence tomography (OCT) Reproducibility of Results Sensitivity and Specificity skin Skin - cytology Skin - drug effects Skin Physiological Phenomena - drug effects Skin Tests - methods Suction Tomography, Optical Coherence - methods ultrasound imaging (UBM) Young Adult |
title | A multitechnique evaluation of topical corticosteroid treatment |
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