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Effect of simvastatin on endothelial function in cardiac syndrome X patients
Patients with cardiac syndrome X with mild hypercholesterolemia were randomized to placebo (n = 20) or simvastatin 20 mg/day (n = 20). In the simvastatin group, there was a significant (26%; p
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Published in: | The American journal of cardiology 2004-09, Vol.94 (5), p.652-655 |
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container_end_page | 655 |
container_issue | 5 |
container_start_page | 652 |
container_title | The American journal of cardiology |
container_volume | 94 |
creator | Fábián, Emília Varga, Albert Picano, Eugenio Vajo, Zoltan Rónaszéki, Aladár Csanády, Miklós |
description | Patients with cardiac syndrome X with mild hypercholesterolemia were randomized to placebo (n = 20) or simvastatin 20 mg/day (n = 20). In the simvastatin group, there was a significant (26%; p |
doi_str_mv | 10.1016/j.amjcard.2004.05.035 |
format | article |
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In the simvastatin group, there was a significant (26%; p <0.0001) decrease in total cholesterol, a 38% (p <0.0001) decrease in low-density lipoprotein cholesterol levels, and 7% a (p <0.0001) increase in high-density lipoprotein cholesterol levels, without significant changes in triglyceride levels. 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In the simvastatin group, there was a significant (26%; p <0.0001) decrease in total cholesterol, a 38% (p <0.0001) decrease in low-density lipoprotein cholesterol levels, and 7% a (p <0.0001) increase in high-density lipoprotein cholesterol levels, without significant changes in triglyceride levels. Brachial artery flow-mediated dilation increased significantly (52% relative increase, p <0.0001), and the time to >1-mm ST-segment depression during stress testing was longer by the end of the study (p <0.0001).</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>15342302</pmid><doi>10.1016/j.amjcard.2004.05.035</doi><tpages>4</tpages></addata></record> |
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subjects | Aged Anticholesteremic Agents - pharmacology Anticholesteremic Agents - therapeutic use Biological and medical sciences Cardiology Cardiovascular disease Circulatory system Drug therapy Endothelium, Vascular - drug effects Endothelium, Vascular - physiopathology Exercise - physiology Female Humans Hypercholesterolemia - complications Hypercholesterolemia - drug therapy Male Medical sciences Metabolic diseases Microvascular Angina - complications Microvascular Angina - drug therapy Middle Aged Miscellaneous Myocardial Ischemia - complications Myocardial Ischemia - drug therapy Other metabolic disorders Simvastatin - pharmacology Simvastatin - therapeutic use Treatment Outcome |
title | Effect of simvastatin on endothelial function in cardiac syndrome X patients |
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