Coacervate Formation from Natural Glycolipid:  One Acetyl Group on the Headgroup Triggers Coacervate-to-Vesicle Transition

Coacervate (L3 phase) formation of the single component “natural” glycoliped biosurfactant, MEL-A, was observed for the first time by using an optical microscope, a confocal laser scanning microscope (CLSM), and a freeze-fracture electron microscope (FF-TEM). It was also found that only a slight dec...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2004-09, Vol.126 (35), p.10804-10805
Main Authors: Imura, T, Yanagishita, H, Kitamoto, D
Format: Article
Language:English
Subjects:
Biological and medical sciences
Colloids - chemistry
Disperse state. Micelles
Erythritol - analogs & derivatives
Freeze Fracturing
Fundamental and applied biological sciences. Psychology
Glycolipids - chemistry
Microscopy, Electron
Molecular biophysics
Physico-chemical properties of biomolecules
Structure-Activity Relationship
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Summary:Coacervate (L3 phase) formation of the single component “natural” glycoliped biosurfactant, MEL-A, was observed for the first time by using an optical microscope, a confocal laser scanning microscope (CLSM), and a freeze-fracture electron microscope (FF-TEM). It was also found that only a slight decrease in spontaneous curvature resulting from the absence of one acetyl group on the headgroup induced a drastic morphological change in the 3D self-assembled structure from coacervates (L3 phase) to ordered vesicles (Lα phase).
ISSN:0002-7863
1520-5126
DOI:10.1021/ja0400281