A Synthetic DNA Walker for Molecular Transport

Inspired by kinesin movement along a microtubule, we demonstrate a processive bipedal DNA walker. Powered by externally controlled DNA fuel strands, the walker locomotes with a 5 nm stride by advancing the trailing foot to the lead at each step. Real-time monitoring of specific bidirectional walker...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2004-09, Vol.126 (35), p.10834-10835
Main Authors: Shin, Jong-Shik, Pierce, Niles A
Format: Article
Language:English
Subjects:
Base Sequence
Biological and medical sciences
Biomimetic Materials - chemistry
Biomimetic Materials - metabolism
DNA - chemistry
DNA - metabolism
Fundamental and applied biological sciences. Psychology
General aspects
Kinesin - chemistry
Kinesin - metabolism
Models, Molecular
Molecular biophysics
Molecular Motor Proteins - chemical synthesis
Molecular Motor Proteins - chemistry
Molecular Motor Proteins - metabolism
Molecular Sequence Data
Oligonucleotides - chemical synthesis
Oligonucleotides - chemistry
Oligonucleotides - metabolism
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Description
Summary:Inspired by kinesin movement along a microtubule, we demonstrate a processive bipedal DNA walker. Powered by externally controlled DNA fuel strands, the walker locomotes with a 5 nm stride by advancing the trailing foot to the lead at each step. Real-time monitoring of specific bidirectional walker movement is achieved via multiplexed fluorescence quenching.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja047543j