Integrins: dynamic scaffolds for adhesion and signaling in platelets

• Published in: Blood 2004-09, Vol.104 (6), p.1606-1615
• Main Authors: Shattil, Sanford J., Newman, Peter J.
• Format: Article
• Language: English
• Subjects: Animals; Biological and medical sciences; Blood and lymphatic vessels; Blood coagulation. Blood cells; Blood Platelets - cytology; Blood Platelets - metabolism; Cardiology. Vascular system; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Fundamental and applied biological sciences. Psychology; Humans; Integrins - chemistry; Integrins - metabolism; Integrins - ultrastructure; Medical sciences; Molecular and cellular biology; Platelet; Platelet Adhesiveness; Protein Binding; Signal Transduction
• ISSN: 0006-4971; 1528-0020
• DOI: 10.1182/blood-2004-04-1257

The major platelet integrin, αIIbβ3, is required for platelet interactions with proteins in plasma and the extracellular matrices (ECMs) that are essential for platelet adhesion and aggregation during hemo stasis and arterial thrombosis. Lig and binding to αIIbβ3 is controlled by inside-out signals that modulate receptor conformation and clustering. In turn, ligand binding triggers outside-in signals through αIIbβ3 that, when disrupted, can cause a bleeding diathesis. In the past 5 years there has been an explosion of knowledge about the structure and function ofαIIbβ3 and the related integrin, αVβ3. These developments are discussed here, and current models of bidirectional αIIbβ3 signaling are presented as frameworks for future investigations. An understanding that αIIbβ3 functions as a dynamic molecular scaffold for extracellular and intracellular proteins has translated into diagnostic and therapeutic insights relevant to hematology and cardiovascular medicine, and further advances can be anticipated. (Blood. 2004;104:1606-1615)