A comparative evolutionary study of transcription networks. The global role of feedback and hierachical structures

We present a comparative analysis of large-scale topological and evolutionary properties of transcription networks in three species: the two distant bacteria E. coli and B. subtilis, and the yeast S. cerevisiae. The study focuses on the global aspects of feedback and hierarchy in transcriptional reg...

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Bibliographic Details
Published in:Molecular bioSystems 2009-01, Vol.5 (2), p.170-179
Main Authors: Sellerio, A L, Bassetti, B, Isambert, H, Cosentino Lagomarsino, M
Format: Article
Language:English
Subjects:
Bacillus subtilis - genetics
Bacterial Proteins
Dimerization
Escherichia coli
Escherichia coli - genetics
Escherichia coli Proteins - genetics
Evolution, Molecular
Gene Expression Profiling
Gene Expression Regulation, Bacterial
Gene Regulatory Networks
Models, Biological
Models, Statistical
Saccharomyces cerevisiae - genetics
Species Specificity
Transcription Factors - metabolism
Transcription, Genetic
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Summary:We present a comparative analysis of large-scale topological and evolutionary properties of transcription networks in three species: the two distant bacteria E. coli and B. subtilis, and the yeast S. cerevisiae. The study focuses on the global aspects of feedback and hierarchy in transcriptional regulatory pathways. While confirming that gene duplication has a significant impact on the shaping of all the analyzed transcription networks, our results point to distinct trends between the bacteria, which display a hierarchical network structure with short transcription cascades, and yeast, which seems able to sustain a higher wiring complexity, including larger feedback, longer transcription cascades, and the combinatorial use of heterodimers made of duplicate transcription factors, absent in E. coli.
ISSN:1742-206X
1742-2051
DOI:10.1039/b815339f