Cu, Zn- and Mn-superoxide dismutase levels in brains of patients with schizophrenic psychosis

Impaired oxidative stress defense has been reported in blood of both drug-naïve and antipsychotic-treated patients suffering from schizophrenic psychosis, indicating the involvement of free radical metabolism in the pathogenetic processes of schizophrenia. In this study, the concentrations of two is...

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Bibliographic Details
Published in:Journal of Neural Transmission 2004-09, Vol.111 (9), p.1191-1201
Main Authors: Michel, T M, Thome, J, Martin, D, Nara, K, Zwerina, S, Tatschner, T, Weijers, H G, Koutsilieri, E
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antioxidants - metabolism
Brain - enzymology
Brain - physiopathology
Female
Frontal Lobe - enzymology
Frontal Lobe - physiopathology
Humans
Isoenzymes - chemistry
Isoenzymes - metabolism
Male
Middle Aged
Oxidative Stress - physiology
Psychosis
Schizophrenia - enzymology
Schizophrenia - physiopathology
Substantia Innominata - enzymology
Substantia Innominata - physiopathology
Superoxide Dismutase - chemistry
Superoxide Dismutase - metabolism
Up-Regulation - physiology
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Summary:Impaired oxidative stress defense has been reported in blood of both drug-naïve and antipsychotic-treated patients suffering from schizophrenic psychosis, indicating the involvement of free radical metabolism in the pathogenetic processes of schizophrenia. In this study, the concentrations of two isoenzymes of superoxide dismutase (SOD), Cu, Zn- and MnSOD, were determined with ELISA in various cortical (frontal, parietal, temporal and occipital cortex) and subcortical areas (putamen, caudate nucleus, thalamus, and substantia innominata) of post-mortem brain tissue from patients diagnosed with a schizophrenia spectrum disorder and compared with those of controls. Post-mortem brain tissue from individuals without neuropsychiatric disorders served for control. Cu, Zn- and MnSOD levels were significantly increased in frontal cortex and substantia innominata of the index group, respectively. In all other areas both types of SOD remained virtually unchanged. Detection of SOD changes in the brain supports previous reports of alterations of antioxidant indices in blood cells of patients with schizophrenia and suggests a specific neuroanatomical distribution pattern of oxidative stress processes possibly related to the pathophysiology of schizophrenia.
ISSN:0300-9564
1435-1463
DOI:10.1007/s00702-004-0160-9