A chemical epigenetics approach for engineering the in situ biosynthesis of a cryptic natural product from Aspergillus niger

A new fungal metabolite, nygerone A (), featuring a unique 1-phenylpyridin-4(1H)-one core that had previously not been reported from any natural source, has been obtained from Aspergillus niger using a chemical epigenetics methodology.

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2009-02, Vol.7 (3), p.435-438
Main Authors: Henrikson, Jon C, Hoover, Ashley R, Joyner, P Matthew, Cichewicz, Robert H
Format: Article
Language:English
Subjects:
Aspergillus niger - genetics
Aspergillus niger - metabolism
Benzyl Compounds - metabolism
Biological Products - biosynthesis
Drug Discovery
Enzyme Inhibitors - pharmacology
Epigenesis, Genetic - drug effects
Genetic Engineering - methods
Histone Deacetylase Inhibitors
Magnetic Resonance Spectroscopy
Pyridones - metabolism
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Description
Summary:A new fungal metabolite, nygerone A (), featuring a unique 1-phenylpyridin-4(1H)-one core that had previously not been reported from any natural source, has been obtained from Aspergillus niger using a chemical epigenetics methodology.
ISSN:1477-0539
DOI:10.1039/b819208a