Cerebellopontine angle neurenteric cyst with focal malignant features

Neurenteric cysts are uncommon cystic lesions lined by endodermal‐derived epithelium, which are rarely found in the CNS, especially in the intracranial region. Although recurrences and disseminations of these cysts have been reported, only one case of intracranial malignant transformation has previo...

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Bibliographic Details
Published in:Neuropathology 2009-02, Vol.29 (1), p.91-95
Main Authors: Wang, Wei, Piao, Yue‐Shan, Gui, Qiu‐Ping, Zhang, Xing‐Hu, Lu, De‐Hong
Format: Article
Language:English
Subjects:
Adult
Carcinoembryonic Antigen - analysis
Cell Nucleus - pathology
cerebellopontine angle
Cerebellopontine Angle - pathology
Epithelium - metabolism
Epithelium - pathology
Female
focal malignant features
Glial Fibrillary Acidic Protein - analysis
Humans
Immunohistochemistry
intracranial
Keratins - analysis
Magnetic Resonance Imaging
Mitosis
Mucin-1 - analysis
Neural Tube Defects - metabolism
Neural Tube Defects - pathology
Neural Tube Defects - surgery
Neurenteric cyst
S100 Proteins - analysis
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Summary:Neurenteric cysts are uncommon cystic lesions lined by endodermal‐derived epithelium, which are rarely found in the CNS, especially in the intracranial region. Although recurrences and disseminations of these cysts have been reported, only one case of intracranial malignant transformation has previously been described. Here we report a cerebellopontine angle neurenteric cyst in a 26‐year‐old woman. The cyst wall was lined by columnar epithelium with atypical nuclei and high MIB‐1 index. In addition, stromal invasion was found in the subepithelial areas, which shows malignant features. Dissemination was speculated on MRI 6 months after total excision of the original cyst.
ISSN:0919-6544
1440-1789
DOI:10.1111/j.1440-1789.2008.00930.x