novel synthesis of highly substituted imidazo[1,5-a]pyrazine derivatives by 3-CR/2-CR sequence

By combining a three-component reaction of 2, 3-diaminomaleonitrile, ketones and isocyanides with a subsequent reaction of 1,6-dihydropyrazine-2,3-dicarbonitrile derivatives obtained from isocyanide-based three-component reaction with various alkyl and aryl isocyanates or isothiocyanates can be asse...

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Bibliographic Details
Published in:Molecular diversity 2009-02, Vol.13 (1), p.63-67
Main Authors: Shaabani, Ahmad, Maleki, Ali, Mofakham, Hamid
Format: Article
Language:English
Subjects:
2,3-Diaminomaleonitrile
Biochemistry
Biomedical and Life Sciences
Biophysics
Chemical engineering
Chemical synthesis
Cyanides - chemistry
Imidazo[1,5-a]pyrazine
Imidazoles - chemistry
Isocyanate
Isocyanide
Ketones - chemistry
Life Sciences
Models, Chemical
Molecular Structure
Multicomponent reaction
Nitriles - chemistry
Organic Chemistry
Pharmacology
Pharmacy
Polymer Sciences
Pyrazines - chemical synthesis
Pyrazines - chemistry
Short Communication
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Summary:By combining a three-component reaction of 2, 3-diaminomaleonitrile, ketones and isocyanides with a subsequent reaction of 1,6-dihydropyrazine-2,3-dicarbonitrile derivatives obtained from isocyanide-based three-component reaction with various alkyl and aryl isocyanates or isothiocyanates can be assembled a new class of highly substituted imidazo[1,5-a]pyrazine derivatives.
ISSN:1381-1991
1573-501X
DOI:10.1007/s11030-008-9099-3