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Synthesis and antibacterial property of quinolines with potent DNA gyrase activity
Synthesis of a series of novel tetrahydroquinoline annulated heterocycles has been accomplished by intramolecular imino and bisimino Diels–Alder reaction. These compounds were evaluated for their antibacterial activity. All the synthetic compounds, exhibited good antibacterial activity against micro...
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| Published in: | Bioorganic & medicinal chemistry 2009-01, Vol.17 (2), p.660-666 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c412t-5bd16b245dcbe8a8540e8a086fb74c4e61216e6413f069067dbe62bad92654e03 |
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| cites | cdi_FETCH-LOGICAL-c412t-5bd16b245dcbe8a8540e8a086fb74c4e61216e6413f069067dbe62bad92654e03 |
| container_end_page | 666 |
| container_issue | 2 |
| container_start_page | 660 |
| container_title | Bioorganic & medicinal chemistry |
| container_volume | 17 |
| creator | Ramesh, Ekambaram Manian, Rathna Durga R.S. Raghunathan, Ragavachary Sainath, Shilpakala Raghunathan, Malathi |
| description | Synthesis of a series of novel tetrahydroquinoline annulated heterocycles has been accomplished by intramolecular imino and bisimino Diels–Alder reaction. These compounds were evaluated for their antibacterial activity. All the synthetic compounds, exhibited good antibacterial activity against microorganisms of which one of them
7 was found to be as active as the antibiotic ciplofloxacin and is found to have MIC value of 2.5
mg/mL against
Escherichia coli. |
| doi_str_mv | 10.1016/j.bmc.2008.11.058 |
| format | article |
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7 was found to be as active as the antibiotic ciplofloxacin and is found to have MIC value of 2.5
mg/mL against
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| fulltext | fulltext |
| identifier | ISSN: 0968-0896 |
| ispartof | Bioorganic & medicinal chemistry, 2009-01, Vol.17 (2), p.660-666 |
| issn | 0968-0896 1464-3391 |
| language | eng |
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| source | ScienceDirect Journals |
| subjects | Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology Antibacterial Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Bisquinolone Ciprofloxacin Escherichia coli Escherichia coli - drug effects Gyrase Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments Quinolines - chemical synthesis Quinolines - pharmacology Quinolone Structure-Activity Relationship Topoisomerase II Inhibitors |
| title | Synthesis and antibacterial property of quinolines with potent DNA gyrase activity |
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