Cranberry Phytochemical Extract Inhibits SGC-7901 Cell Growth and Human Tumor Xenografts in Balb/c nu/nu Mice

• Published in: Journal of agricultural and food chemistry 2009-01, Vol.57 (2), p.762-768
• Main Authors: Liu, Ming, Lin, Luo-Qiang, Song, Bing-Bing, Wang, Li-Feng, Zhang, Chun-Peng, Zhao, Jin-Lu, Liu, Jia-Ren
• Format: Article
• Language: English
• Subjects: adenocarcinoma; Animals; anticarcinogenic activity; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - pharmacology; apoptosis; Biological and medical sciences; Cell Line, Tumor; cell proliferation; Cell Proliferation - drug effects; Cell Survival - drug effects; cranberries; Feeding. Feeding behavior; Food industries; Fruit and vegetable industries; fruit extracts; Fundamental and applied biological sciences. Psychology; Humans; in vitro studies; medicinal properties; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms - drug therapy; Neoplasms - metabolism; Neoplasms - physiopathology; Plant Extracts - chemistry; Plant Extracts - pharmacology; Proliferating Cell Nuclear Antigen - metabolism; Random Allocation; stomach neoplasms; Toxicology in Agriculture and Food; Vaccinium macrocarpon - chemistry; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Xenograft Model Antitumor Assays; xenotransplantation
• ISSN: 0021-8561; 1520-5118
• DOI: 10.1021/jf802780k

Cranberry extract possesses potent antioxidant capacity and antiproliferative activity against cancer in vitro and in vivo. The objectives of this study were to determine whether the cranberry extract inhibited proliferation of human gastric cancer SGC-7901 cells and human gastric tumor xenografts in the Balb/c nu/nu mouse. Cranberry extract at doses of 0, 5, 10, 20, and 40 mg/mL significantly inhibited proliferation of SGC-7901 cells, and this suppression was partly attributed to decreased PCNA expression and apoptosis induction. In a human tumor xenograft model, the time of human gastric tumor xenografts in the mouse was delayed in a dose-dependent manner. A dose−response inhibition was also observed in the averages of size, weight, and volume of tumor xenografts in the mouse between the control and cranberry-treated groups. These results demonstrate fresh cranberries to be a chemopreventive reagent.