Accumulation of soluble inflammatory mediators between blood donation and pre-storage leucocyte depletion

Background and Objectives   Leucocyte‐derived cytokines accumulate in stored whole blood. Pre‐storage leucocyte depletion has reduced cytokine levels and, consequently, febrile non‐haemolytic transfusion reactions. As leucocyte filtration and component separation can be performed until 24 h after do...

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Bibliographic Details
Published in:Vox sanguinis 2009-02, Vol.96 (2), p.163-166
Main Authors: Chudziak, D., Sireis, W., Pfeiffer, H.-U., Henschler, R., Seifried, E., Bönig, H.
Format: Article
Language:English
Subjects:
Blood & organ donations
Blood Donors
Blood Preservation
Blood products
cytokine
Cytokines
Fever - etiology
FNHTR
Humans
Inflammation Mediators - blood
Leukocyte Reduction Procedures
Leukocytes
pre-storage leukocyte depletion
Solubility
Time Factors
Transfusion Reaction
whole-blood storage
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Summary:Background and Objectives   Leucocyte‐derived cytokines accumulate in stored whole blood. Pre‐storage leucocyte depletion has reduced cytokine levels and, consequently, febrile non‐haemolytic transfusion reactions. As leucocyte filtration and component separation can be performed until 24 h after donation, we hypothesized that within this time, inflammatory cytokines might accumulate. Materials and Methods   Serial plasma samples were collected 4, 10 and 20 h after donation and cytokine concentrations were measured. Results   Interleukin‐8 increased > 20‐fold and soluble CD40 ligand > sixfold during the observation time, less pronounced changes for several other mediators were also observed. Conclusion   Leucocyte depletion within 10 h of blood donation will reduce the concentrations of pyrogenic mediators.
ISSN:0042-9007
1423-0410
DOI:10.1111/j.1423-0410.2008.01132.x