Apical Plasma Membrane Traffic in Superficial Cells of Bladder Urothelium

Superficial urothelial cells that line the urinary bladder accommodate cyclical changes in organ volume while maintaining a permeability barrier between urine and tissue fluids. The specific apical plasma membrane traffic is necessary for their proper function. The composition of the apical plasma m...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2009-01, Vol.1152 (1), p.18-29
Main Authors: Kreft, Mateja Erdani, Jezernik, Kristijan, Kreft, Marko, Romih, Rok
Format: Article
Language:English
Subjects:
Animals
Biological Transport
bladder pathology
Cell Membrane - metabolism
Cell Membrane - secretion
Cell Membrane - ultrastructure
differentiation
Endocytosis
Exocytosis
Humans
Urinary Bladder - metabolism
Urinary Bladder - secretion
Urinary Bladder - ultrastructure
urothelium
Urothelium - metabolism
Urothelium - secretion
Urothelium - ultrastructure
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Summary:Superficial urothelial cells that line the urinary bladder accommodate cyclical changes in organ volume while maintaining a permeability barrier between urine and tissue fluids. The specific apical plasma membrane traffic is necessary for their proper function. The composition of the apical plasma membrane is dramatically modified during differentiation of bladder urothelial cells, most notably by assembly of urothelial plaques containing uroplakins. However, the assembly of uroplakins into plaques, their insertion and removal from the apical surface, and the regulation of these processes are still poorly understood. This review examines the traffic (exocytosis/endocytosis) of the apical plasma membrane during differentiation of urothelial cells and focuses on the physiological and clinical significance of the apical plasma membrane traffic in bladder superficial urothelial cells.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2008.04004.x