Short communication: Haptoglobin as an early indicator of metritis

• Published in: Journal of dairy science 2009-02, Vol.92 (2), p.621-625
• Main Authors: Huzzey, J.M., Duffield, T.F., LeBlanc, S.J., Veira, D.M., Weary, D.M., von Keyserlingk, M.A.G.
• Format: Article
• Language: English
• Subjects: accuracy; Animal productions; Animals; Biological and medical sciences; blood chemistry; body temperature; calving; Cattle; cattle diseases; Cattle Diseases - blood; Cattle Diseases - diagnosis; dairy cows; diagnostic techniques; disease diagnosis; disease prevention; disease severity; Endometriosis - blood; Endometriosis - veterinary; endometritis; Female; Food industries; Fundamental and applied biological sciences. Psychology; haptoglobin; haptoglobins; Haptoglobins - metabolism; inflammation; metritis; Milk and cheese industries. Ice creams; prediction; Predictive Value of Tests; Pregnancy; signs and symptoms (animals and humans); temporal variation; Terrestrial animal productions; test sensitivity; test specificity; Time Factors; transition cow; vaginal discharge; Vertebrates
• ISSN: 0022-0302; 1525-3198
• DOI: 10.3168/jds.2008-1526

The purpose of this study was to determine whether haptoglobin (Hp) could be used as a predictive measure for metritis. Cattle were grouped into 3 health categories based on the condition of vaginal discharge and body temperature after calving: severe metritis (n=12), mild metritis (n=32), and healthy (n=23). Blood was collected and analyzed for Hp concentration on d −20±5, −6±2, −2±1, and d 0 relative to calving, and then every 3 d after calving until d +21. Cows with mild and severe metritis had greater Hp concentrations than healthy cows between d 0 and d +12. Mean (±SE) Hp concentrations peaked on d +3 in the cows with mild metritis (1.06±0.15g/L) and on d +6 in cows with severe metritis (1.62±0.47g/L). Mean concentrations for the healthy group were 0.58±0.12g/L and 0.31±0.08g/L on d +3 and d +6, respectively. Clinical signs of pathological discharge for the mildly and severely metritic cows did not occur until, on average, 8.6±3.9 d and 5.3±1.9 d after calving, respectively. Cows with Hp concentrations ≥1g/L on d +3 were 6.7 times more likely to develop severe or mild metritis; this predictive threshold has a sensitivity of 50% and specificity of 87%. These results indicate that an acute phase inflammatory response precedes clinical metritis and that Hp screening may assist in the early detection of metritis, providing increased opportunities for early treatment and prevention.