Phosphorylation of Myosin Regulatory Light Chain by Myosin Light Chain Kinase, and Muscle Contraction

Not only muscle contraction, but also most cell movements depend on myosin - actin interaction using ATP. Many components of the contraction machinery are involved in the efficient coupling of energy source and force development. Among these, I have focused on myosin light chain kinase (MLCK) in thi...

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Bibliographic Details
Published in:Circulation Journal 2009, Vol.73(2), pp.208-213
Main Author: Takashima, Seiji
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Calcium - metabolism
Homeostasis - physiology
Humans
Muscle contraction
Muscle Contraction - physiology
Myosin light chain kinase
Myosin Light Chains - metabolism
Myosin-Light-Chain Kinase - analysis
Myosin-Light-Chain Kinase - metabolism
Phosphorylation
Regulatory light chain
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Summary:Not only muscle contraction, but also most cell movements depend on myosin - actin interaction using ATP. Many components of the contraction machinery are involved in the efficient coupling of energy source and force development. Among these, I have focused on myosin light chain kinase (MLCK) in this review. MLCK phosphorylates myosin regulatory light chain and controls all 3 types of muscle contraction: skeletal muscle, smooth muscle, and cardiac muscle. However, each muscle has specific MLCK and the role of MLCK in each muscle is different. This difference explains the specific role of each muscle in vivo and contributes to the activity of various force development in different ways in each tissue. Therefore, I also review the differences in the connection between each MLCK and muscle contraction in the 3 muscle types. (Circ J 2009; 73: 208 - 213)
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.CJ-08-1041