Decreased plasma concentrations of adiponectin in patients with slow coronary flow

• Published in: Heart and vessels 2009, Vol.24 (1), p.1-7
• Main Authors: Selcuk, Hatice, Selcuk, Mehmet Timur, Temizhan, Ahmet, Maden, Orhan, Saydam, Gul Sevim, Ulupinar, Hakan, Dogan, Mehmet, Aydın, Cengiz, Topcu, Deniz I., Sasmaz, Ali
• Format: Article
• Language: English
• Subjects: Adiponectin - blood; Biomedical Engineering and Bioengineering; Cardiac Surgery; Cardiology; Cardiovascular disease; Coronary Angiography; Coronary Circulation - physiology; Coronary Disease - blood; Coronary Disease - diagnostic imaging; Coronary Disease - physiopathology; Coronary vessels; Coronary Vessels - physiopathology; Endothelium, Vascular - physiopathology; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Humans; Male; Medicine; Medicine & Public Health; Middle Aged; Original Article; Pathology; Prognosis; Proteins; Regional Blood Flow - physiology; Risk factors; Severity of Illness Index; Vascular Surgery
• ISSN: 0910-8327; 1615-2573
• DOI: 10.1007/s00380-008-1074-5

Adiponectin has multiple protective effects on vascular endothelium through anti-inflammatory and anti-atherogenic properties. Recent data suggested that endothelial activation and inflammation may contribute to the pathogenesis of slow coronary flow (SCF). Therefore, we investigated whether adiponectin plasma concentrations were decreased in patients with SCF compared to subjects with normal coronary flow. The study population consisted of 35 patients with angiographically documented SCF in all three coronary arteries and 35 sex- and age-matched cases with normal coronary flow. Coronary flow rates of all participants were determined by Thrombolysis in Myocardial Infarction (TIMI) frame count. Plasma adiponectin concentrations were measured by an enzyme-linked immunosorbent assay method using commercially available adiponectin kits. There were no statistically significant differences between the patients with SCF and the subjects with normal coronary flow in terms of demographic characteristics and cardiovascular risk factors ( P > 0.05). Plasma adiponectin concentrations of patients with SCF were found to be significantly lower than those with normal coronary flow (4.77 ± 3.86 mg/ml vs 10.8 ± 6.60 mg/ml, P = 0.001, respectively). Plasma adiponectin levels were correlated significantly and inversely with mean TIMI frame count in patients with SCF ( r = −0.441, P = 0.008). Furthermore, the Receiver Operator Characteristics curve of adiponectin concentrations showed that an adiponectin