Pulmonary Neoplasia in Two Llamas (Lama glama)

Two llamas with pulmonary tumors were examined. Llama No. 1 had multiple nodules throughout the lung that consisted histologically of solid clusters of polygonal to spindle cells with rare glandular differentiation. Intravascular emboli were common. Similar neoplastic masses were present in the kidn...

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Bibliographic Details
Published in:Veterinary pathology 2004-09, Vol.41 (5), p.520-523
Main Authors: Ramos-Vara, J. A., Loiacono, C. M., Williams, F., Pardo, I., Lakritz, J.
Format: Article
Language:English
Subjects:
Animals
Camelids, New World
Carcinoma, Adenosquamous - pathology
Carcinoma, Adenosquamous - veterinary
Diagnosis, Differential
Fatal Outcome
Female
Immunohistochemistry - veterinary
Keratins - metabolism
Lung Neoplasms - pathology
Lung Neoplasms - veterinary
Male
Vimentin - metabolism
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Summary:Two llamas with pulmonary tumors were examined. Llama No. 1 had multiple nodules throughout the lung that consisted histologically of solid clusters of polygonal to spindle cells with rare glandular differentiation. Intravascular emboli were common. Similar neoplastic masses were present in the kidney, heart, and liver. Immunohistochemically, neoplastic cells were positive for broad-spectrum cytokeratins (CKs), high- molecular weight CKs, CKs 5/6, and vimentin. The diagnosis was pulmonary carcinoma. Llama No. 2 had pulmonary nodules without extrapulmonary involvement. Microscopically, neoplastic cells formed acini lined by simple epithelium and solid cords of squamous cells that sometimes surrounded acini. Neoplastic cells were strongly positive for broad-spectrum CKs and weakly positive for thyroid transcription factor-1. The diagnosis was adenosquamous carcinoma. Pulmonary tumors account for 23% of neoplasms in South American camelids in our laboratory, making this the second most common type of neoplasm after lymphosarcoma.
ISSN:0300-9858
1544-2217
DOI:10.1354/vp.41-5-520