Non-classical karyotypic features in relapsed childhood B-cell precursor acute lymphoblastic leukemia

Abstract Karyotype analysis of acute lymphoblastic leukemia (ALL) at diagnosis has provided valuable prognostic markers for treatment stratification. However, reports of cytogenetic studies of relapsed ALL samples are limited. We compared the karyotypes from 436 nonselected B-cell precursor ALL pati...

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Published in:Cancer genetics and cytogenetics 2009-02, Vol.189 (1), p.29-36
Main Authors: Wehrli, Lea A, Braun, Julia, Buetti, Luisa Nobile, Hagleitner, Nicole, Hengartner, Heinz, Kühne, Thomas, Lüer, Sonja, Ozsahin, Hulya, Popovic, Maja Beck, Niggli, Felix K, Betts, David R, Bourquin, Jean-Pierre
Format: Article
Language:English
Subjects:
Acute Disease
Adolescent
Child
Child, Preschool
Chromosome Aberrations
Female
Hematology, Oncology and Palliative Medicine
Humans
Infant
Karyotyping
Male
Medical Education
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - prevention & control
Recurrence
Translocation, Genetic
Treatment Outcome
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Summary:Abstract Karyotype analysis of acute lymphoblastic leukemia (ALL) at diagnosis has provided valuable prognostic markers for treatment stratification. However, reports of cytogenetic studies of relapsed ALL samples are limited. We compared the karyotypes from 436 nonselected B-cell precursor ALL patients at initial diagnosis and of 76 patients at first relapse. We noticed a relative increase of karyotypes that did not fall into the classic ALL cytogenetic subgroups (high hyperdiploidy, t(12;21), t(9;22), 11q23, t(1;19),
ISSN:0165-4608
1873-4456
DOI:10.1016/j.cancergencyto.2008.10.002