Zoledronic acid for the treatment of appendicular osteosarcoma in a dog

A 10-year-old male intact Corso dog was referred for lameness and for a large neoplasm affecting the right foreleg. Physical examination of the patient revealed a 5 x 5 x 3 cm mass in the distal right foreleg. Histopathology was consistent with a diagnosis of appendicular osteosarcoma. The staging p...

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Bibliographic Details
Published in:Journal of small animal practice 2009, Vol.50 (1), p.44-46
Main Authors: Spugnini, E.P, Vincenzi, B, Caruso, G, Baldi, A, Citro, G, Santini, D, Tonini, G
Format: Article
Language:English
Subjects:
analgesic effect
Animals
anticarcinogenic activity
antineoplastic agents
bisphosphonates
Bone Density Conservation Agents - administration & dosage
bone diseases
Bone Neoplasms - diagnostic imaging
Bone Neoplasms - drug therapy
Bone Neoplasms - veterinary
bone resorption
case studies
Diphosphonates - administration & dosage
disease diagnosis
dog diseases
Dog Diseases - diagnostic imaging
Dog Diseases - drug therapy
Dogs
drug therapy
Euthanasia, Animal
Forelimb - diagnostic imaging
forelimbs
Imidazoles - administration & dosage
lameness
Lameness, Animal - complications
Lymph Node Excision
lymph nodes
Lymphatic Metastasis
Male
metastasis
osteosarcoma
Osteosarcoma - diagnostic imaging
Osteosarcoma - drug therapy
Osteosarcoma - veterinary
phosphonates
Radiography
signs and symptoms (animals and humans)
zoledronic acid
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Summary:A 10-year-old male intact Corso dog was referred for lameness and for a large neoplasm affecting the right foreleg. Physical examination of the patient revealed a 5 x 5 x 3 cm mass in the distal right foreleg. Histopathology was consistent with a diagnosis of appendicular osteosarcoma. The staging process found no evidence of metastasis. Because of the large size of the patient, the owners elected to treat their dog with antiresorptive therapy. The patient was treated with an infusion of zoledronic acid every 28 days. The tumour remained stable for 16 months and the lameness of the dog greatly improved. At that time, the patient returned for evaluation of a large rapidly growing prescapular mass. Biopsy confirmed lymph node metastasis and the dog was euthanased. Zoledronic acid showed remarkable palliation in our patient and possibly anti-tumour action and warrants further investigation.
ISSN:0022-4510
1748-5827
DOI:10.1111/j.1748-5827.2008.00635.x