Bioassay-Guided Isolation of Xanthones and Polycyclic Prenylated Acylphloroglucinols from Garcinia oblongifolia

Bioassay-guided fractionation of the acetone extract of the bark of Garcinia oblongifolia has resulted in the isolation of three new xanthones, oblongixanthones A−C (1−3), three new polyprenylated benzoylphloroglucinols, oblongifolins E−G (4−6), and 12 known compounds. Oblongifolins I (5) and J (6)...

Full description

Saved in:
Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2009-01, Vol.72 (1), p.130-135
Main Authors: Huang, Sheng-Xiong, Feng, Chao, Zhou, Yan, Xu, Gang, Han, Quan-Bin, Qiao, Chun-Feng, Chang, Donald C, Luo, Kathy Qian, Xu, Hong-Xi
Format: Article
Language:English
Subjects:
anticarcinogenic activity
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
apoptosis
Biological and medical sciences
chemical structure
cultured cells
cytotoxicity
Drug Screening Assays, Antitumor
Drugs, Chinese Herbal - chemistry
Drugs, Chinese Herbal - isolation & purification
Drugs, Chinese Herbal - pharmacology
Garcinia
Garcinia - chemistry
Garcinia oblongifolia
General pharmacology
HeLa Cells
human diseases
Humans
Medical sciences
medicinal properties
Molecular Structure
oblongifolin
oblongixanthone
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
phloroglucinol
phytochemicals
Plant Bark - chemistry
Plants, Medicinal - chemistry
spectral analysis
stereochemistry
xanthones
Xanthones - chemistry
Xanthones - isolation & purification
Xanthones - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Bioassay-guided fractionation of the acetone extract of the bark of Garcinia oblongifolia has resulted in the isolation of three new xanthones, oblongixanthones A−C (1−3), three new polyprenylated benzoylphloroglucinols, oblongifolins E−G (4−6), and 12 known compounds. Oblongifolins I (5) and J (6) are the first natural products that have similar structural features to those of two known oxidation products of garcinol. The structures of the new compounds 1−6 were characterized by spectroscopic data interpretation. All isolates were assayed for their apoptosis-inducing effects against HeLa-C3 cells. Oblongifolin C (16) was found to be the most potent apoptotic inducer of the compounds evaluated.
ISSN:0163-3864
1520-6025
DOI:10.1021/np800496c